Following a Master in physiology, cellular and molecular biology at the University of Poitiers in France, Dr. ElAli earned a Doctorate (Dr. rer nat) in cellular and molecular neuroscience from the University of Duisburg-Essen in Germany, jointly with the University of Zurich in Switzerland. Afterwards, he completed a first postdoctoral training in vascular neurology in cerebrovascular diseases at the Research center of the University Hospital Center of Essen in Germany. He then completed a second postdoctoral training in neuroimmunology in cerebrovascular and neurodegenerative diseases at the Research Center of CHU de Québec – Laval University. Dr. ElAli has joined the Department of Psychiatry and Neuroscience at Laval University in July 2015. He is the recipient of a career award from the Fonds de recherche du Québec-Santé (FRQS), and has previously received several career awards and prizes of excellence, mainly from the German Research Foundation ‘Deutsche Forschungsgemeinschaft (DFG)’, and the ‘Dr Werner Jackstaedt-Stiftung’ Foundation in Germany.

Cerebrovascular diseases mainly include strokes, which constitute a major cause of death and disability in Canadian adults. The great majority of cases are ischemic, caused by the occlusion of a cerebral artery by a blood clot. Beyond thrombolysis that aims at restoring the cerebral blood circulation by dissolving the clot, no effective disease-modifying treatment exists. Recent studies, including those performed by Dr. ElAli, have outlined the presence of a structural and functional remodelling process of the network of cells that constitutes the neurovascular unit following a stroke. This network includes endothelial cells, pericytes, astrocytes, microglia, and neurons that work together to enable the proper functioning of the brain. Emerging evidence suggests that the remodelling process decisively influences the regeneration of the injured tissue, thus providing new perspectives for the development of innovative interventions in stroke therapies.

Dr. ElAli’s research program aims to explore the cellular and molecular mechanisms involved in the remodelling of the neurovascular unit following a stroke. He is particularly interested in endothelial cells and pericytes as these two cell types constitute the core of the neurovascular unit. The endothelial cells form the blood-brain barrier that plays an essential role in maintaining the brain homeostasis. The pericytes play a crucial role in stabilization of the vascular system, and act as pluripotent cells capable to be differentiated into vascular, glial and neuronal cells. Dr. ElAli’s laboratory strategy consists of targeting specialized molecular mechanisms in the endothelial cells in order to restore the blood-brain barrier, and the function of pericytes in order to stabilize the vascular system and promote the regenerative potential of these cells. The ultimate goal of this strategy is to re-establish the integrity of the neurovascular unit as a way of regenerating the injured tissue.

CHUL
2705, boulevard Laurier
T-2-33
Québec, Québec
Canada G1V 4G2
44 entries « 1 of 5 »

Lecordier S, Manrique-Castano D, El Moghrabi Y, ElAli A

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors.

Journal Article

Front Aging Neurosci, 13 , 2021.

Abstract | Links:

Al-Onaizi MA, Thériault P, Lecordier S, Rivest S, ElAli A

fvEarly monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression.

Journal Article

Brain Behav Immun, 2021.

Abstract | Links:

Menet R, Lecordier S, ElAli A

Wnt Pathway: An Emerging Player in Vascular and Traumatic Mediated Brain Injuries.

Journal Article

Front Physiol, 11 , 2020.

Abstract | Links:

Al-Onaizi M, Al-Khalifah A, Qasem D, ElAli A

Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration.

Journal Article

Int J Mol Sci, 21 (18), 2020.

Abstract | Links:

Jean LeBlanc N, Menet R, Picard K, Parent G, Tremblay ME, ElAli A

Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy.

Journal Article

Mol Neurobiol, 56 (9), 2019.

Abstract | Links:

Menet R, Bernard M, ElAli A

Hyperlipidemia in Stroke Pathobiology and Therapy: Insights and Perspectives.

Journal Article

Front Physiol, 9 , 2018.

| Links:

Jean LeBlanc N, Guruswamy R, ElAli A

Vascular Endothelial Growth Factor Isoform-B Stimulates Neurovascular Repair After Ischemic Stroke by Promoting the Function of Pericytes via Vascular Endothelial Growth Factor Receptor-1.

Journal Article

Mol Neurobiol, 55 (5), 2018.

Abstract | Links:

Guruswamy R, ElAli A

Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions.

Journal Article

Int J Mol Sci, 18 (3), 2017.

Abstract | Links:

Jackson S, ElAli A, Virgintino D, Gilbert MR

Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer's disease.

Journal Article

Neuro Oncol, 19 (9), 2017.

Abstract | Links:

ElAli A, Rivest S

Microglia Ontology and Signaling.

Journal Article

Front Cell Dev Biol, 4 , 2016.

Abstract | Links:

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Active projects

  • Bourse de soutien aux nouveaux détenteurs de Chaire de recherche du Canada, from 2020-07-01 to 2022-06-30
  • Canada Research Chair in molecular and cellular neurovascular interactions, from 2020-07-01 to 2025-06-30
  • Mechanisms regulating contribution of pericytes to brain repair after stroke, from 2020-04-01 to 2025-03-31
  • Role of canonical Wnt pathway in regulating the structural and functional integrity of the blood-brain barrier in the normal adult brain, from 2017-04-01 to 2022-03-31
  • The role of apolipoprotein E4-canonical Wnt pathway crosstalk at the blood-brain barrier in Alzheimer’s disease, from 2017-10-30 to 2021-12-31

Recently finished projects

  • 3rd Neuroforum of the CHU de Québec - Université Laval Research Center: A seminar series of le2aders in neuroscience, from 2020-01-01 to 2020-03-31
  • Laboratory of inter-cellular dynamics within the neurovascular unit in cerebrovascular diseases, from 2018-01-01 to 2021-07-31
  • Neurovascular Restoration in Stroke: Role of Dickkopf-Related Protein-1 (DKK1), from 2018-07-01 to 2021-06-30
  • Signalisation de l’unité neurovasculaire suite aux maladies cérébrovasculaires: Implications pathobiologiques et thérapeutiques, from 2017-07-01 to 2020-06-30
  • Signalisation de l’unité neurovasculaire suite aux maladies cérébrovasculaires: Implications pathobiologiques et thérapeutiques, from 2017-07-01 to 2020-06-30
Data provided by the Université Laval research projects registery