Arnaud Droit is an associate professor with the Department of Molecular Medicine at Laval University’s School of Medicine, and a researcher at the CHU de Québec–Laval University Research Centre, where he heads the bioinformatics and proteomics platform. He is also a member of the executive directorate of Laval University’s Big Data Research Centre (CRDM). Arnaud Droit studied biochemistry and bioinformatics at Université Toulouse III – Paul Sabatier, in France, and holds a PhD from Laval University.

Dr. Droit’s research program aims at developing new approaches and methods in computational genomics to analyze the genomic and proteomic data collected, effectively and thoroughly, using next-generation technology. His work is at the crossroads of biology and computer science.

Since 2016, he holds the L’Oréal Chair in Research and Innovation in Digital Biology, the first research chair in digital biology, which constitutes a center of excellence for the development of multi-omic big data technologies (which include the different fields of biology ending with the suffix “omic”: genomic, epigenomic, proteomic, metagenomic, etc.) and analyses.

Dr. Droit oversees a number of large-scale projects that address the challenges of managing massive data and extracting actionable knowledge for the life science community. One of his projects aims to aggregate many biological data sources, link them together, discover new relationships, and make them available on the Internet via dynamic visualization interfaces. He is also involved in the development of machine learning tools dedicated to clinical research and multi-omics data, which can also be extended to other areas. Other projects also cover temporal multi-omic data analysis, which requires the development of new approaches, and the identification of genes interacting together through the creation of coexpression networks.

Finally, Dr. Droit has established many international collaborations that allow him to cover a variety of fields in biology research, including oncology, immunology, and skin diseases.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
R-4773
Québec, Québec
Canada G1V 4G2
62 entries « 1 of 13 »

Belleau P, Deschenes A, Scott-Boyer MP, Dalvai M, Bailey J, Droit A

Inferring and modeling inheritance of differentially methylated changes across multiple generations.

Journal Article

Nucleic Acids Res, 2018, ISSN: 0305-1048.

Abstract | Links:

Tourancheau A, Rouleau M, Guauque-Olarte S, Villeneuve L, Gilbert I, Droit A, Guillemette C

Quantitative profiling of the UGT transcriptome in human drug-metabolizing tissues.

Journal Article

Pharmacogenomics J, 18 (2), pp. 251-261, 2018, ISSN: 1470-269X.

Abstract | Links:

Vincent AT, Bourbonnais Y, Brouard JS, Deveau H, Droit A, Gagne SM, Guertin M, Lemieux C, Rathier L, Charette SJ, Lague P

Implementing a web-based introductory bioinformatics course for non-bioinformaticians that incorporates practical exercises.

Journal Article

Biochem Mol Biol Educ, 46 (1), pp. 31-38, 2018, ISSN: 1470-8175.

Abstract | Links:

Aumailley L, Roux-Dalvai F, Kelly I, Droit A, Lebel M

Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.

Journal Article

PLoS ONE, 13 (3), pp. e0193170, 2018.

Abstract | Links:

Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindstrom S, Hui S, Lemacon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, Wang Q, Aalfs CM, ABCTB Investigators, Adams M, Adlard J, Agata S, Ahmed S, Ahsan H, Aittomaki K, Al-Ejeh F, Allen J, Ambrosone CB, Amos CI, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Arnold N, Aronson KJ, Auber B, Auer PL, Ausems MGEM, Azzollini J, Bacot F, Balmana J, Barile M, Barjhoux L, Barkardottir RB, Barrdahl M, Barnes D, Barrowdale D, Baynes C, Beckmann MW, Benitez J, Bermisheva M, Bernstein L, Bignon YJ, Blazer KR, Blok MJ, Blomqvist C, Blot W, Bobolis K, Boeckx B, Bogdanova NV, Bojesen A, Bojesen SE, Bonanni B, Borresen-Dale AL, Bozsik A, Bradbury AR, Brand JS, Brauch H, Brenner H, Bressac-de Paillerets B, Brewer C, Brinton L, Broberg P, Brooks-Wilson A, Brunet J, Bruning T, Burwinkel B, Buys SS, Byun J, Cai Q, Caldes T, Caligo MA, Campbell I, Canzian F, Caron O, Carracedo A, Carter BD, Castelao JE, Castera L, Caux-Moncoutier V, Chan SB, Chang-Claude J, Chanock SJ, Chen X, Cheng TD, Chiquette J, Christiansen H, Claes KBM, Clarke CL, Conner T, Conroy DM, Cook J, Cordina-Duverger E, Cornelissen S, Coupier I, Cox A, Cox DG, Cross SS, Cuk K, Cunningham JM, Czene K, Daly MB, Damiola F, Darabi H, Davidson R, De Leeneer K, Devilee P, Dicks E, Diez O, Ding YC, Ditsch N, Doheny KF, Domchek SM, Dorfling CM, Dork T, Dos-Santos-Silva I, Dubois S, Dugue PA, Dumont M, Dunning AM, Durcan L, Dwek M, Dworniczak B, Eccles D, Eeles R, Ehrencrona H, Eilber U, Ejlertsen B, Ekici AB, Eliassen AH, EMBRACE, Engel C, Eriksson M, Fachal L, Faivre L, Fasching PA, Faust U, Figueroa J, Flesch-Janys D, Fletcher O, Flyger H, Foulkes WD, Friedman E, Fritschi L, Frost D, Gabrielson M, Gaddam P, Gammon MD, Ganz PA, Gapstur SM, Garber J, Garcia-Barberan V, Garcia-Saenz JA, Gaudet MM, Gauthier-Villars M, Gehrig A, GEMO Study Collaborators, Georgoulias V, Gerdes AM, Giles GG, Glendon G, Godwin AK, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Goodfellow P, Greene MH, Alnaes GIG, Grip M, Gronwald J, Grundy A, Gschwantler-Kaulich D, Guenel P, Guo Q, Haeberle L, Hahnen E, Haiman CA, Hakansson N, Hallberg E, Hamann U, Hamel N, Hankinson S, Hansen TVO, Harrington P, Hart SN, Hartikainen JM, Healey CS, HEBON, Hein A, Helbig S

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

Journal Article

Nat Genet, 49 (12), pp. 1767-1778, 2017, ISSN: 1061-4036.

Abstract | Links:

62 entries « 1 of 13 »

Active projects

  • Calcul Québec, Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques, from 2015-04-01 to 2021-03-31
  • Centre de recherche en données massives, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2016-06-07 to 2021-06-06
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Chaire de recherche et d'innovation l'Oréal en biologie numérique, Subvention, L'Oréal, Chaires de recherche sans organismes subventionnaires, from 2016-05-16 to 2021-05-15
  • Combination of Wnt-ß-catenin, androgen receptor and PD-1 inhibition for the therapy of bladder cancer, Subvention, Cancer de la vessie Canada, Research Grant Program 2017, from 2018-01-01 to 2018-12-31
  • Dietary microRNAs, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2019-03-31
  • Effect of environmental contaminants and methylome of breast adipose tissue on aromatase inhibitor efficacy in breast cancer, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2020-06-30
  • Father's lasting influence:Molecular foundations of intergenerational transmission of the paternal environment, Subvention, Instituts de recherche en santé du Canada, Subvention d'équipe : La santé des garçons et des hommes, from 2014-11-01 to 2019-10-31
  • Identification et quantification de biomarqueurs responsables de l'activité biofongicide et bioinsecticide produites par des souches de Bacillus, Partenariat, Conseil de recherches en sciences naturelles et génie Canada, Subventions de recherche et développement coopérative (RDC), from 2016-05-10 to 2019-05-09
  • Identifying novel molecular insights from life science massive data, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2018-04-01 to 2023-03-31
  • Impact of the sperm epigenome on the progeny outcome born by assisted reproductive technology, Subvention, Sick Kids Foundation (The), New Investigator Research Grants, from 2016-07-01 to 2019-06-30
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II), Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31
  • Pharmacogenomics of human UDP-glucuronosyltransferases: From single genetic polymorphisms to a complex regulation of enzyme function, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-04-01 to 2019-03-31
  • Prédisposition, prédiction et prévention du cancer du sein, Subvention, Ministère de l'Économie, de l'Innovation et des Exportations, Programme de soutien à la recherche (PSR-V4) : Programme de soutien à des initiatives internationales de recherche et d'innovation (SIIRI), from 2016-04-01 to 2019-03-31
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, Subvention, Instituts de recherche en santé du Canada, Fonctionnement: Subvention de promotion de l’impact - CCREES, from 2017-10-01 to 2020-09-30

Recently finished projects

  • Centre de recherche sur les données massives (CRDM), Subvention, Institutionnel - BDR, BDR - Cas spéciaux et obligations institutionnelles, from 2015-05-01 to 2017-04-30
  • Coupling metabolomic and proteomic approaches in profiling endobiotics metabolism, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2012-04-01 to 2017-03-31
  • Dissecting in vivo the biological role of the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) in ovarian cancer cell invasiveness and its possible implication in aberrant O-glycosylation of mucin-like targets., Subvention, Société de recherche sur le cancer, Subvention de fonctionnement, from 2014-09-01 to 2017-02-28
  • Epigenomic control of prostatic inflammation., Subvention, Cancer de la prostate Canada, Subventions d'équipe Movember (Movember Discovery Grants), from 2014-07-01 to 2016-12-31
  • Human and Microbial Integrative Genomics, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds de l'avant-garde (FA), from 2012-09-01 to 2016-08-31
  • Personalized risk stratification for prevention and early detection of breast cancer, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2013-04-01 to 2018-03-31
  • Profilage moléculaire des adénocarcinomes pulmonaires multiples synchrones: Identification de cibles moléculaires potentielles. (fonds 0493), Subvention, Fondation de l'Université Laval, from 2014-11-05 to 2017-12-31
  • Soutien aux jeunes professeurs., Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2012-01-01 to 2016-12-31
  • Soutien facultaire aux jeunes professeurs, Subvention, Université Laval - budget de fonctionnement, Bourses pour les nouveaux professeurs chercheurs à la Faculté de médecine, from 2012-01-01 to 2016-12-31
  • WikiTrauma: Implementation and evaluation of a WIKI involving multiple stakeholders including patients in the promotion of best practices in TRAUMA care (an interrupted time series), Subvention, Canadian Medical Protective Association (The), from 2014-11-07 to 2016-06-30
Data provided by the Université Laval research projects registery