Arnaud Droit is an associate professor with the Department of Molecular Medicine at Laval University’s School of Medicine, and a researcher at the CHU de Québec–Laval University Research Centre, where he heads the bioinformatics and proteomics platform. He is also a member of the executive directorate of Laval University’s Big Data Research Centre (CRDM). Arnaud Droit studied biochemistry and bioinformatics at Université Toulouse III – Paul Sabatier, in France, and holds a PhD from Laval University.

Dr. Droit’s research program aims at developing new approaches and methods in computational genomics to analyze the genomic and proteomic data collected, effectively and thoroughly, using next-generation technology. His work is at the crossroads of biology and computer science.

Since 2016, he holds the L’Oréal Chair in Research and Innovation in Digital Biology, the first research chair in digital biology, which constitutes a center of excellence for the development of multi-omic big data technologies (which include the different fields of biology ending with the suffix “omic”: genomic, epigenomic, proteomic, metagenomic, etc.) and analyses.

Dr. Droit oversees a number of large-scale projects that address the challenges of managing massive data and extracting actionable knowledge for the life science community. One of his projects aims to aggregate many biological data sources, link them together, discover new relationships, and make them available on the Internet via dynamic visualization interfaces. He is also involved in the development of machine learning tools dedicated to clinical research and multi-omics data, which can also be extended to other areas. Other projects also cover temporal multi-omic data analysis, which requires the development of new approaches, and the identification of genes interacting together through the creation of coexpression networks.

Finally, Dr. Droit has established many international collaborations that allow him to cover a variety of fields in biology research, including oncology, immunology, and skin diseases.

CHUL
2705, boulevard Laurier
R-4789
Québec, Québec
Canada G1V 4G2
87 entries « 1 of 9 »

Mailhot B, Christin M, Tessandier N, Sotoudeh C, Bretheau F, Turmel R, Pellerin E, Wang F, Bories C, Joly-Beauparlant C, De Koninck Y, Droit A, Cicchetti F, Scherrer G, Boilard E, Sharif-Naeini R, Lacroix S

Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases.

Journal Article

J Exp Med, 217 (9), 2020, ISSN: 0022-1007.

Abstract | Links:

Girardet L, Bernet A, Calvo E, Soulet D, Joly-Beauparlant C, Droit A, Cyr DG, Belleannee C

Hedgehog signaling pathway regulates gene expression profile of epididymal principal cells through the primary cilium.

Journal Article

FASEB J, 34 (6), pp. 7593-7609, 2020, ISSN: 0892-6638.

Abstract | Links:

Allain EP, Rouleau M, Vanura K, Tremblay S, Vaillancourt J, Bat V, Caron P, Villeneuve L, Labriet A, Turcotte V, Le T, Shehata M, Schnabl S, Demirtas D, Hubmann R, Joly-Beauparlant C, Droit A, Jager U, Staber PB, Levesque E, Guillemette C

UGT2B17 modifies drug response in chronic lymphocytic leukaemia.

Journal Article

Br J Cancer, 2020, ISSN: 0007-0920.

Abstract | Links:

Khorraminezhad L, Leclercq M, O'Connor S, Julien P, Weisnagel SJ, Gagnon C, Droit A, Rudkowska I

Dairy product intake modifies gut microbiota composition among hyperinsulinemic individuals.

Journal Article

Eur J Nutr, 2020, ISSN: 1436-6207.

Abstract | Links:

Mesquita I, Ferreira C, Moreira D, Kluck GEG, Barbosa AM, Torrado E, Dinis-Oliveira RJ, Goncalves LG, Beauparlant CJ, Droit A, Berod L, Sparwasser T, Bodhale N, Saha B, Rodrigues F, Cunha C, Carvalho A, Castro AG, Estaquier J, Silvestre R

The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis.

Journal Article

Cell Rep, 30 (12), pp. 4052-4064.e7, 2020.

Abstract | Links:

Mehdi S, Bachvarova M, Scott-Boyer MP, Droit A, Bachvarov D

LY75 Ablation Mediates Mesenchymal-Epithelial Transition (MET) in Epithelial Ovarian Cancer (EOC) Cells Associated with DNA Methylation Alterations and Suppression of the Wnt/β-Catenin Pathway.

Journal Article

Int J Mol Sci, 21 (5), 2020.

Abstract | Links:

Levesque E, Labriet A, Hovington H, Allain EP, Melo-Garcia L, Rouleau M, Brisson H, Turcotte V, Caron P, Villeneuve L, Leclercq M, Droit A, Audet-Walsh E, Simonyan D, Fradet Y, Lacombe L, Guillemette C

Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression.

Journal Article

Br J Cancer, 122 (7), pp. 1068-1076, 2020, ISSN: 0007-0920.

Abstract | Links:

Benmoussa A, Laugier J, Beauparlant CJ, Lambert M, Droit A, Provost P

Complexity of the microRNA transcriptome of cow milk and milk-derived extracellular vesicles isolated via differential ultracentrifugation.

Journal Article

J Dairy Sci, 103 (1), pp. 16-29, 2020, ISSN: 0022-0302.

Abstract | Links:

Fachal L, Aschard H, Beesley J, Barnes DR, Allen J, Kar S, Pooley KA, Dennis J, Michailidou K, Turman C, Soucy P, Lemacon A, Lush M, Tyrer JP, Ghoussaini M, Marjaneh MM, Jiang X, Agata S, Aittomaki K, Alonso MR, Andrulis IL, Anton-Culver H, Antonenkova NN, Arason A, Arndt V, Aronson KJ, Arun BK, Auber B, Auer PL, Azzollini J, Balmana J, Barkardottir RB, Barrowdale D, Beeghly-Fadiel A, Benitez J, Bermisheva M, Bialkowska K, Blanco AM, Blomqvist C, Blot W, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Borg A, Bosse K, Brauch H, Brenner H, Briceno I, Brock IW, Brooks-Wilson A, Bruning T, Burwinkel B, Buys SS, Cai Q, Caldes T, Caligo MA, Camp NJ, Campbell I, Canzian F, Carroll JS, Carter BD, Castelao JE, Chiquette J, Christiansen H, Chung WK, Claes KBM, Clarke CL, GEMO Study Collaborators, EMBRACE Collaborators, Collee JM, Cornelissen S, Couch FJ, Cox A, Cross SS, Cybulski C, Czene K, Daly MB, de la Hoya M, Devilee P, Diez O, Ding YC, Dite GS, Domchek SM, Dork T, Dos-Santos-Silva I, Droit A, Dubois S, Dumont M, Duran M, Durcan L, Dwek M, Eccles DM, Engel C, Eriksson M, Evans DG, Fasching PA, Fletcher O, Floris G, Flyger H, Foretova L, Foulkes WD, Friedman E, Fritschi L, Frost D, Gabrielson M, Gago-Dominguez M, Gambino G, Ganz PA, Gapstur SM, Garber J, Garcia-Saenz JA, Gaudet MM, Georgoulias V, Giles GG, Glendon G, Godwin AK, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Tibiletti MG, Greene MH, Grip M, Gronwald J, Grundy A, Guenel P, Hahnen E, Haiman CA, Hakansson N, Hall P, Hamann U, Harrington PA, Hartikainen JM, Hartman M, He W, Healey CS, Heemskerk-Gerritsen BAM, Heyworth J, Hillemanns P, Hogervorst FBL, Hollestelle A, Hooning MJ, Hopper JL, Howell A, Huang G, Hulick PJ, Imyanitov EN, KConFab Investigators, HEBON Investigators, ABCTB Investigators, Isaacs C, Iwasaki M, Jager A, Jakimovska M, Jakubowska A, James PA, Janavicius R, Jankowitz RC, John EM, Johnson N, Jones ME, Jukkola-Vuorinen A, Jung A, Kaaks R, Kang D, Kapoor PM, Karlan BY, Keeman R, Kerin MJ, Khusnutdinova E, Kiiski JI, Kirk J, Kitahara CM, Ko YD, Konstantopoulou I, Kosma VM, Koutros S, Kubelka-Sabit K, Kwong A, Kyriacou K, Laitman Y, Lambrechts D, Lee E, Leslie G, Lester J, Lesueur F, Lindblom A, Lo WY, Long J, Lophatananon A, Loud JT, Lubinski J, MacInnis RJ, Maishman T, Makalic E, Mannermaa A, Manoochehri M

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.

Journal Article

Nat Genet, 52 (1), pp. 56-73, 2020, ISSN: 1061-4036.

Abstract | Links:

Ferreira C, Mesquita I, Barbosa AM, Osorio NS, Torrado E, Beauparlant CJ, Droit A, Cunha C, Carvalho A, Saha B, Estaquier J, Silvestre R

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.

Journal Article

PLoS Negl Trop Dis, 14 (3), pp. e0008125, 2020, ISSN: 1935-2727.

Abstract | Links:

87 entries « 1 of 9 »
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Active projects

  • Calcul Québec, Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2015-04-01 to 2021-03-31
  • Cellular mechanisms regulating the pathogenesis of secondary progressive CNS autoimmunity, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-10-01 to 2023-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en données massives, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2016-06-07 to 2021-06-06
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Chaire de recherche et d'innovation l'Oréal en biologie numérique, Subvention, L'Oréal, Chaires de recherche sans organismes subventionnaires, from 2016-05-16 to 2021-05-15
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-03-01 to 2021-02-28
  • Development of Comprehensive Cytogenomics and Molecular Genetics Testing Using ans Exome and Low-Pass Whole Genome Sequencing Combined Approach, Partenariat, Génome Canada, Projets de recherche appliquée à grande échelle - Large-Scale Applied Research Project, from 2019-01-01 to 2021-12-31
  • Développement d'un nouvel instrument d'analyse en temps réel pour la chirurgie guidée des cancers, Subvention, Fonds de recherche du Québec - Nature et technologies, Programme Samuel-De Champlain, from 2019-04-01 to 2021-03-31
  • Identifying novel molecular insights from life science massive data, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2018-04-01 to 2023-03-31
  • Leveraging the impact of diversity in neurodevelopmental disability by integrating machine learning in personalized interventions, Subvention, Instituts de recherche en santé du Canada, Canada-UK Artificial Intelligence Initiative, from 2020-02-01 to 2023-01-31
  • Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique, Subvention, Fonds de recherche du Québec - Société et culture, Appel à propositions : création d’un Observatoire international sur les impacts sociétaux de l’intelligence artificielle et du numérique, from 2018-04-01 to 2024-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II), Subvention, Génome Canada, Projets de recherche appliquée à grande échelle - Large-Scale Applied Research Project, from 2017-11-01 to 2022-03-31
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, Subvention, Instituts de recherche en santé du Canada, Fonctionnement: Subvention de promotion de l’impact - CCREES, from 2017-10-01 to 2020-09-30
  • Use of genomics to manage and protect caribou populations, Subvention, Génome Canada, Programme de partenariats pour les applications de la génomique (PPAG), from 2018-04-01 to 2021-03-31

Recently finished projects

  • Father's lasting influence:Molecular foundations of intergenerational transmission of the paternal environment, Subvention, Instituts de recherche en santé du Canada, Subvention d'équipe : La santé des garçons et des hommes, from 2014-11-01 to 2019-10-31
  • Frame shift mutation-induced on the microbiome, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Sentinelle Nord - Projets conjoints avec Université Côte d'Azur / IDEX, from 2018-10-01 to 2019-09-30
  • Identification et quantification de biomarqueurs responsables de l'activité biofongicide et bioinsecticide produites par des souches de Bacillus, Partenariat, Conseil de recherches en sciences naturelles et génie Canada, Subventions de recherche et développement coopérative (RDC), from 2016-05-10 to 2020-03-31
  • Impact of the sperm epigenome on the progeny outcome born by assisted reproductive technology, Subvention, Sick Kids Foundation (The), New Investigator Research Grants, from 2016-07-01 to 2019-06-30
  • Targeting PD-1 and TIGIT pathways for the immunotherapy of bladder cancer, Subvention, Association canadienne d'urologie, from 2018-11-23 to 2019-11-22
Data provided by the Université Laval research projects registery