Arnaud Droit is an associate professor with the Department of Molecular Medicine at Laval University’s School of Medicine, and a researcher at the CHU de Québec–Laval University Research Centre, where he heads the bioinformatics and proteomics platform. He is also a member of the executive directorate of Laval University’s Big Data Research Centre (CRDM). Arnaud Droit studied biochemistry and bioinformatics at Université Toulouse III – Paul Sabatier, in France, and holds a PhD from Laval University.

Dr. Droit’s research program aims at developing new approaches and methods in computational genomics to analyze the genomic and proteomic data collected, effectively and thoroughly, using next-generation technology. His work is at the crossroads of biology and computer science.

Since 2016, he holds the L’Oréal Chair in Research and Innovation in Digital Biology, the first research chair in digital biology, which constitutes a center of excellence for the development of multi-omic big data technologies (which include the different fields of biology ending with the suffix “omic”: genomic, epigenomic, proteomic, metagenomic, etc.) and analyses.

Dr. Droit oversees a number of large-scale projects that address the challenges of managing massive data and extracting actionable knowledge for the life science community. One of his projects aims to aggregate many biological data sources, link them together, discover new relationships, and make them available on the Internet via dynamic visualization interfaces. He is also involved in the development of machine learning tools dedicated to clinical research and multi-omics data, which can also be extended to other areas. Other projects also cover temporal multi-omic data analysis, which requires the development of new approaches, and the identification of genes interacting together through the creation of coexpression networks.

Finally, Dr. Droit has established many international collaborations that allow him to cover a variety of fields in biology research, including oncology, immunology, and skin diseases.

CHUL
2705, boulevard Laurier
Québec, Québec
Canada G1V 4G2
117 entries « 1 of 12 »

Lambert M, Benmoussa A, Diallo I, Ouellet-Boutin K, Dorval V, Majeau N, Joly-Beauparlant C, Droit A, Bergeron A, Têtu B, Fradet Y, Pouliot F, Provost P

Identification of Abundant and Functional dodecaRNAs (doRNAs) Derived from Ribosomal RNA.

Journal Article

Int J Mol Sci, 22 (18), 2021.

Abstract | Links:

Bodein A, Scott-Boyer MP, Perin O, Lê Cao KA, Droit A

timeOmics: an R package for longitudinal multi-omics data integration.

Journal Article

Bioinformatics, 2021.

Abstract | Links:

Maurice C, Dalvai M, Lambrot R, Deschênes A, Scott-Boyer MP, McGraw S, Chan C, Côté N, Ziv-Gal A, Flaws JA, Droit A, Trasler J, Kimmins S, Bailey JL

Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage

Journal Article

Epigenomes, 5 (2), 2021, ISSN: 2075-4655.

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Cossus L, Roux-Dalvai F, Kelly I, Nguyen TTA, Antoun H, Droit A, Tweddell RJ

Interactions with plant pathogens influence lipopeptides production and antimicrobial activity of Bacillus subtilis strain PTB185

Journal Article

Biol Control, 154 , 2021, ISSN: 1049-9644.

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Bramble MS, Vashist N, Ko A, Priya S, Musasa C, Mathieu A, Spencer A, Lupamba Kasendue M, Mamona Dilufwasayo P, Karume K, Nsibu J, Manya H, Uy MNA, Colwell B, Boivin M, Mayambu JPB, Okitundu D, Droit A, Mumba Ngoyi D, Blekhman R, Tshala-Katumbay D, Vilain E

The gut microbiome in konzo.

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Gotti C, Roux-Dalvai F, Joly-Beauparlant C, Mangnier L, Leclercq M, Droit A

Extensive and Accurate Benchmarking of DIA Acquisition Methods and Software Tools Using a Complex Proteomic Standard.

Journal Article

J Proteome Res, 20 (10), 2021.

Abstract | Links:

Brooks JD, Nabi HH, Andrulis IL, Antoniou AC, Chiquette J, Després P, Devilee P, Dorval M, Droit A, Easton DF, Eisen A, Eloy L, Fienberg S, Goldgar D, Hahnen E, Joly Y, Knoppers BM, Lofters A, Masson JY, Mittmann N, Paquette JS, Pashayan N, Schmutzler R, Stockley T, Tavtigian SV, Walker MJ, Wolfson M, Chiarelli AM, Simard J

Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I).

Journal Article

J Pers Med, 11 (6), 2021.

Abstract | Links:

Laflamme N, Lace B, Thonta Setty S, Rioux N, Labrie Y, Droit A, Chrestian N, Rivest S

A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy.

Journal Article

Front Neurol, 12 , 2021.

Abstract | Links:

Picard M, Scott-Boyer MP, Bodein A, Périn O, Droit A

Integration strategies of multi-omics data for machine learning analysis.

Journal Article

Comput Struct Biotechnol J, 19 , 2021.

Abstract | Links:

Bourgeois R, Bourgault J, Despres AA, Perrot N, Guertin J, Girard A, Mitchell PL, Gotti C, Bourassa S, Scipione CA, Gaudreault N, Boffa MB, Koschinsky ML, Pibarot P, Droit A, Thériault S, Mathieu P, Bossé Y, Arsenault BJ

Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis.

Journal Article

Metabolites, 11 (7), 2021.

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117 entries « 1 of 12 »
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Active projects

  • Calcul Québec, from 2015-04-01 to 2022-03-31
  • Caractérisation de la structure 3D et de la coloration des perles chez Pinctada sp. par analyse d’image., from 2021-01-01 to 2023-12-31
  • Caribou Genomics : a National Non-Invasive Monitoring Approach for an Iconic and Model Species-at-Risk, from 2020-10-01 to 2023-09-30
  • Cellular mechanisms regulating the pathogenesis of secondary progressive CNS autoimmunity, from 2018-10-01 to 2023-03-31
  • Chaire de recherche et d'innovation l'Oréal en biologie numérique, from 2016-05-16 to 2026-05-15
  • Computer-Aided Sperm Analysis (CASA) of sperm motility and hyperactivation, from 2021-04-01 to 2022-03-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2022-05-31
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, from 2020-03-01 to 2025-03-31
  • Dévelooppement d'algorithmes d'interprétation de modèles d'apprentissage profond pour la découverte de biomarqueurs, from 2020-04-01 to 2022-03-31
  • Development of Comprehensive Cytogenomics and Molecular Genetics Testing Using ans Exome and Low-Pass Whole Genome Sequencing Combined Approach, from 2019-01-01 to 2021-12-31
  • Développement d'approches par apprentissage actif et en budget contraint à partir de données de cardiologie, from 2021-08-01 to 2021-10-29
  • Identifying novel molecular insights from life science massive data, from 2018-04-01 to 2023-03-31
  • Impact of the sperm epigenome on the progeny outcome born by assisted reproductive technology, from 2016-07-01 to 2021-12-31
  • Influence of hyperglycemia on the host-microbiome interactions during subgingival microbiome dysbiosis, from 2020-12-11 to 2022-06-10
  • Leveraging the impact of diversity in neurodevelopmental disability by integrating machine learning in personalized interventions, from 2020-02-01 to 2023-01-31
  • Nouvelle approche moléculaire pour la détection simultanée des virus pathogènes aux framboisiers et aux fraisiers, from 2019-08-01 to 2023-08-31
  • Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique, from 2018-04-01 to 2024-03-31
  • Outil d'intelligence artificielle pour l'identification rapide et précise des bactéries pathogènes chez les animaux et/ou chez l'humain dans le lait et les produits laitiers, from 2021-04-01 to 2024-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II), from 2017-11-01 to 2022-03-31
  • Predict to prevent: Advanced proteomics profiling for precision medicine, from 2021-03-23 to 2022-09-30
  • Prevention of the immunopathology induced by SARS-CoV-2, from 2021-06-01 to 2022-05-31
  • Therapeutic approach to preserve Tfh cells and improve B cell immunity in simian immunodeficiency virus infected rhesus macaques, from 2021-04-01 to 2026-03-31
  • Une infrastructure IA multi-usagers clé en main pour gérer le cycle de vie complet des données en santé, from 2021-04-01 to 2021-11-30
  • Use of genomics to manage and protect caribou populations, from 2018-04-01 to 2022-03-31
  • Utilisation du séquençage à haut débit pour l’identification d’organismes pathogènes des plantes, from 2019-08-01 to 2023-08-31

Recently finished projects

  • Développement d'un nouvel instrument d'analyse en temps réel pour la chirurgie guidée des cancers, from 2019-04-01 to 2021-03-31
  • Father's lasting influence: Molecular foundations of intergenerational transmission of the paternal environment, from 2014-11-01 to 2021-03-31
  • Frame shift mutation-induced on the microbiome, from 2018-10-01 to 2019-09-30
  • Identification et quantification de biomarqueurs responsables de l'activité biofongicide et bioinsecticide produites par des souches de Bacillus, from 2016-05-10 to 2020-03-31
  • Live viral spectroscopy for rapid Covid-19 detection applied directly to clinical biofluids without sample processing, from 2020-08-01 to 2021-07-31
  • Mise en place d’une application web d’aide à la visualisation et à l’interprétation des analyses de la qualité des sols en culture de pommes de terre, from 2019-05-17 to 2021-05-16
  • Targeting PD-1 and TIGIT pathways for the immunotherapy of bladder cancer, from 2018-11-23 to 2019-11-22
  • Toward nutritional and epigenomic interventions in prostate cancer prevention and management, from 2017-10-01 to 2020-09-30
Data provided by the Université Laval research projects registery