Dr. Ariane Mackey is a neurologist specializing in cerebrovascular diseases at the CHU of Quebec and Associate Professor of Medicine at Laval University. She is the Director of the Neurovascular Research Center, which consists of a team of neurologists specializing in cerebrovascular diseases, Dr. Steve Verreault and Dr. Marie-Christine Camden, as well as research nurses.

As a clinician and local principal investigator or co-investigator, she is actively involved in the review, as well as the implementation of large-scale multicentre clinical studies, either in the acute phase of ischemic or hemorrhagic stroke, as well as in secondary prevention, including carotid stenosis. The results of these studies sometimes lead to the rapid modification of practical guides on certain subjects, such as the CREST study which compared carotid endarterectomy to carotid stenting for patients with symptomatic or asymptomatic carotid stenosis. This study has shown that stent revascularization resulted in slightly more periprocedural stroke, while endarterectomy resulted in slightly more myocardial infarction. However, both procedures were found to be equally safe. It was also demonstrated, in agreement with other studies, that beyond 70 years of age, endarterectomy was the procedure of choice whereas, below 70 years of age, the stent was a very good option. The currently ongoing study on carotid stenosis is CREST 2; the goal is to demonstrate that maximal or even aggressive medical treatment would be as effective as stent or surgical revascularization in patients with asymptomatic severe stenosis.

The other main studies in progress concern patients who had a cryptogenic stroke, that is to say without a proven source of embolism, where we compare a direct anticoagulant versus aspirin alone. This aims to demonstrate whether a direct anticoagulant is more effective in preventing recurrence, while remaining safe in terms of the risk of bleeding.

The neurovascular team also participates in acute phase clinical trials of ischemic stroke with TNKase, as well as in a study to demonstrate the efficacy of a neuroprotective as adjunctive therapy to mechanical thrombectomy.

1401, 18e Rue
Québec, Québec
Canada G1J 1Z4

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Hart RG, Sharma M, Mundl H, Kasner SE, Bangdiwala SI, Berkowitz SD, Swaminathan B, Lavados P, Wang Y, Davalos A, Shamalov N, Mikulik R, Cunha L, Lindgren A, Arauz A, Lang W, Czlonkowska A, Eckstein J, Gagliardi RJ, Amarenco P, Ameriso SF, Tatlisumak T, Veltkamp R, Hankey GJ, Toni D, Bereczki D, Uchiyama S, Ntaios G, Yoon BW, Brouns R, Endres M, Muir KW, Bornstein N, Ozturk S, O'Donnell MJ, De Vries Basson MM, Pare G, Pater C, Kirsch B, Sheridan P, Peters G, Weitz JI, Peacock WF, Shoamanesh A, Benavente OR, Joyner C, Themeles E, Connolly SJ, NAVIGATE ESUS Investigators

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source.

Journal Article

N Engl J Med, 378 (23), pp. 2191-2201, 2018, ISSN: 0028-4793.

Abstract | Links:

Kasner SE, Lavados P, Sharma M, Wang Y, Davalos A, Shamalov N, Cunha L, Lindgren A, Mikulik R, Arauz A, Lang W, Czlonkowska A, Eckstein J, Gagliardi R, Amarenco P, Ameriso SF, Tatlisumak T, Veltkamp R, Hankey GJ, Toni DS, Bereczki D, Uchiyama S, Ntaios G, Yoon BW, Brouns R, DeVries Basson MM, Endres M, Muir K, Bornstein N, Ozturk S, O'Donnell M, Mundl H, Pater C, Weitz J, Peacock WF, Swaminathan B, Kirsch B, Berkowitz SD, Peters G, Pare G, Themeles E, Shoamanesh A, Connolly SJ, Hart RG, NAVIGATE ESUS Steering Committee, Investigators

Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial.

Journal Article

J Stroke Cerebrovasc Dis, 27 (6), pp. 1673-1682, 2018, ISSN: 1052-3057.

Abstract | Links:

Masson-Roy J, Savard M, Mackey A

Carotid Cavernous Fistula in a Patient with Type IV Ehlers-Danlos Syndrome.

Journal Article

Can J Neurol Sci, 44 (4), pp. 427-428, 2017, ISSN: 0317-1671.

| Links:

Khandhar SJ, Bowling MR, Flandes J, Gildea TR, Hood KL, Krimsky WS, Minnich DJ, Murgu SD, Pritchett M, Toloza EM, Wahidi MM, Wolvers JJ, Folch EE, NAVIGATE Study Investigators

Electromagnetic navigation bronchoscopy to access lung lesions in 1,000 subjects: first results of the prospective, multicenter NAVIGATE study.

Journal Article

BMC Pulm Med, 17 (1), pp. 59, 2017.

Abstract | Links:

Michelson KN, Frader J, Sorce L, Clayman ML, Persell SD, Fragen P, Ciolino JD, Campbell LC, Arenson M, Aniciete DY, Brown ML, Ali FN, White D, Navigate Study Investigators

The Process and Impact of Stakeholder Engagement in Developing a Pediatric Intensive Care Unit Communication and Decision-Making Intervention.

Journal Article

J Patient Exp, 3 (4), pp. 108-118, 2016, ISSN: 2374-3735.

Abstract | Links:

42 entries « 1 of 9 »

Active projects

  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31

Recently finished projects

  • Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2), Subvention, National Institute of Health (USA), Subvention de recherche, from 2015-03-01 to 2017-03-31
  • Carotid revascularization endarterectomy vs stenting trial, Subvention, National Institute of Health (USA), Subvention de recherche, from 2004-04-07 to 2017-12-31
  • Diagnosis of uncertain-origin benign transient neurological symptoms (DOUBT), Subvention, Université de Calgary, from 2013-04-01 to 2017-03-31
  • Insulin Resistance Intervention after Stroke (IRIS) Trial, Subvention, National Institute of Health (USA), Subvention de recherche, from 2004-12-08 to 2016-12-31
Data provided by the Université Laval research projects registery