Dr. Ariane Mackey is a neurologist specializing in cerebrovascular diseases at the CHU of Quebec and Associate Professor of Medicine at Laval University. She is the Director of the Neurovascular Research Center, which consists of a team of neurologists specializing in cerebrovascular diseases, Dr. Steve Verreault and Dr. Marie-Christine Camden, as well as research nurses.

As a clinician and local principal investigator or co-investigator, she is actively involved in the review, as well as the implementation of large-scale multicentre clinical studies, either in the acute phase of ischemic or hemorrhagic stroke, as well as in secondary prevention, including carotid stenosis. The results of these studies sometimes lead to the rapid modification of practical guides on certain subjects, such as the CREST study which compared carotid endarterectomy to carotid stenting for patients with symptomatic or asymptomatic carotid stenosis. This study has shown that stent revascularization resulted in slightly more periprocedural stroke, while endarterectomy resulted in slightly more myocardial infarction. However, both procedures were found to be equally safe. It was also demonstrated, in agreement with other studies, that beyond 70 years of age, endarterectomy was the procedure of choice whereas, below 70 years of age, the stent was a very good option. The currently ongoing study on carotid stenosis is CREST 2; the goal is to demonstrate that maximal or even aggressive medical treatment would be as effective as stent or surgical revascularization in patients with asymptomatic severe stenosis.

The other main studies in progress concern patients who had a cryptogenic stroke, that is to say without a proven source of embolism, where we compare a direct anticoagulant versus aspirin alone. This aims to demonstrate whether a direct anticoagulant is more effective in preventing recurrence, while remaining safe in terms of the risk of bleeding.

The neurovascular team also participates in acute phase clinical trials of ischemic stroke with TNKase, as well as in a study to demonstrate the efficacy of a neuroprotective as adjunctive therapy to mechanical thrombectomy.

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Cortel-LeBlanc MA, Sharma M, Cortel-LeBlanc A, Sivilotti MLA, Émond M, Stiell IG, Stotts G, Lee J, Worster A, Morris J, Cheung KW, Jin AY, Oczkowski WJ, Sahlas DJ, Murray HE, Mackey A, Verreault S, Camden MC, Yip S, Teal P, Gladstone DJ, Boulos MI, Chagnon N, Shouldice E, Atzema C, Slaoui T, Teitelbaum J, Abdulaziz KE, Wells GA, Taljaard M, Perry JJ

Predictors of neurologists confirming or overturning emergency physicians' diagnosis of TIA or stroke.

Journal Article

CJEM, 23 (6), 2021.

Abstract | Links:

Nogueira RG, Qureshi MM, Abdalkader M, Martins SO, Yamagami H, Qiu Z, Mansour OY, Sathya A, Czlonkowska A, Tsivgoulis G, Aguiar de Sousa D, Demeestere J, Mikulik R, Vanacker P, Siegler JE, Korv J, Biller J, Liang CW, Sangha NS, Zha AM, Czap AL, Holmstedt CA, Turan TN, Ntaios G, Malhotra K, Tayal A, Loochtan A, Ranta A, Mistry EA, Alexandrov AW, Huang DY, Yaghi S, Raz E, Sheth SA, Mohammaden MH, Frankel M, Bila Lamou EG, Aref HM, Elbassiouny A, Hassan F, Menecie T, Mustafa W, Shokri HM, Roushdy T, Sarfo FS, Alabi TO, Arabambi B, Nwazor EO, Sunmonu TA, Wahab K, Yaria J, Mohammed HH, Adebayo PB, Riahi AD, Gwaunza L, Ngwende GW, Sahakyan D, Rahman A, Ai Z, Bai F, Duan Z, Hao Y, Huang W, Li G, Li W, Liu G, Luo J, Shang X, Sui Y, Tian L, Wen H, Wu B, Yan Y, Yuan Z, Zhang H, Zhang J, Zhao W, Zi W, Leung TW, Chugh C, Huded V, Menon B, Pandian JD, Sylaja PN, Usman Sr, Farhoudi M, Hokmabadi ES, Horev A, Reznik A, Ohara N, Sakai N, Watanabe D, Yamamoto R, Doijiri R, Tokuda N, Yamada T, Terasaki T, Yazawa Y, Uwatoko T, Dembo T, Shimizu H, Sugiura Y, Miyashita F, Fukuda H, Miyake K, Shimbo J, Sugimura Y, Yagita Y, Takenobu Y, Matsumaru Y, Yamada S, Kono R, Kanamaru T, Yamazaki H, Sakaguchi M, Todo K, Yamamoto N, Sonoda K, Yoshida T, Hashimoto H, Nakahara I, Kondybayeva A, Faizullina K, Kamenova S, Zhanuzakov M, Baek JH, Hwang Y, Lee JS, Lee SB, Moon J, Park H, Seo JH, Seo KD, Sohn SI, Young CJ, Ahdab R, Wan Zaidi WA, Aziz ZA, Basri HB, Chung LW, Ibrahim AB, Ibrahim KA, Looi I, Tan WY, Yahya NW, Groppa S, Leahu P, Al Hashmi AM, Imam YZ, Akhtar N, Pineda-Franks MC, Co CO, Kandyba D, Alhazzani A, Al-Jehani H, Tham CH, Mamauag MJ, Venketasubramanian N, Chen CH, Tang SC, Churojana A, Akil E, Aykac O, Ozdemir AO, Giray S, Hussain SI, John S, Le Vu H, Tran AD, Nguyen HH, Nguyen TH, Nguyen TQ, Gattringer T, Enzinger C, Killer-Oberpfalzer M, Bellante F, De Blauwe S, Vanhooren G, De Raedt S, Dusart A, Lemmens R, Ligot N, Yperzeele L, Alexiev F, Sakelarova T, Bedekovic MR, Budincevic H, Cindric I, Hucika Z, Ozretic D, Saric MS, Pfeifer F, Karpowic I, Cernik D, Sramek M, Skoda M, Hlavacova H, Klecka L, Koutny M, Vaclavik D, Skoda O, Fiksa J, Hanelova K, Nevsimalova M, Rezek R, Prochazka P, Krejstova G, Neumann J, Vachova M, Brzezanski H, Hlinovsky D, Tenora D

Global Impact of COVID-19 on Stroke Care and IV Thrombolysis.

Journal Article

Neurology, 96 (23), 2021.

Abstract | Links:

Perry JJ, Sivilotti MLA, Emond M, Stiell IG, Stotts G, Lee J, Worster A, Morris J, Cheung KW, Jin AY, Oczkowski WJ, Sahlas DJ, Murray HE, Mackey A, Verreault S, Camden MC, Yip S, Teal P, Gladstone DJ, Boulos MI, Chagnon N, Shouldice E, Atzema C, Slaoui T, Teitlebaum J, Abdulaziz K, Nemnom MJ, Wells GA, Sharma M

Prospective validation of Canadian TIA Score and comparison with ABCD2 and ABCD2i for subsequent stroke risk after transient ischaemic attack: multicentre prospective cohort study.

Journal Article

BMJ, 372 , 2021.

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Mavaddat N, Antoniou AC, Mooij TM, Hooning MJ, Heemskerk-Gerritsen BA, Nogues C, Gauthier-Villars M, Caron O, Gesta P, Pujol P, Lortholary A, Mackey A, Verreault S, Barrowdale D, Frost D, Evans DG, Izatt L, Adlard J, Eeles R, Brewer C, Tischkowitz M, Henderson A, Cook J, Eccles D, van Engelen K, Mourits MJE, Ausems MGEM, Koppert LB, Hopper JL, John EM, Chung WK, Andrulis IL, Daly MB, Buys SS, Benitez J, Caldes T, Jakubowska A, Simard J, Singer CF, Tan Y, Olah E, Navratilova M, Foretova L, Gerdes AM, Roos-Blom MJ, Van Leeuwen FE, Arver B, Olsson H, Schmutzler RK, Engel C, Kast K, Phillips KA, Terry MB, Milne RL, Goldgar DE, Rookus MA, Andrieu N, Easton DF, Durocher F, Laborde L, Breysse E, Stoppa-Lyonnet D, Buecher B, Fourme-Mouret E, Fricker JP, Lasset C, Bonadona V, Berthet P, Faivre L, Luporsi E, Mari V, Gladieff L, Sobol H, Eisinger F, Longy M, Dugast C, Colas C, Coupier I, Corsini C, Vennin P, Adenis C, Nguyen TD, Delnatte C, Tinat J, Tennevet I, Limacher JM, Maugard C, Bignon YJ, Demange L, Penet C, Dreyfus H, Cohen-Haguenauer O, Venat-Bouvet L, Leroux D, Zattara-Cannoni H, Fert-Ferrer S, Bera O, Ellis S, Hogervorst FBL, Collée JM, van Asperen CJ, Mensenkamp AR, Meijers-Heijboer HEJ, Blok MJ, Oosterwijk JC, Verloop J, van den Broek E

Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers.

Journal Article

Breast Cancer Res, 22 (1), 2020.

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Lal BK, Roubin GS, Jones M, Clark W, Mackey A, Hill MD, Voeks JH, Howard G, Hobson 2nd, Brott TG

Influence of multiple stents on periprocedural stroke after carotid artery stenting in the Carotid Revascularization Endarterectomy versus Stent Trial (CREST).

Journal Article

J Vasc Surg, 69 (3), 2019.

Abstract | Links:

Kasner SE, Lavados P, Sharma M, Wang Y, Davalos A, Shamalov N, Cunha L, Lindgren A, Mikulik R, Arauz A, Lang W, Czlonkowska A, Eckstein J, Gagliardi R, Amarenco P, Ameriso SF, Tatlisumak T, Veltkamp R, Hankey GJ, Toni DS, Bereczki D, Uchiyama S, Ntaios G, Yoon BW, Brouns R, DeVries Basson MM, Endres M, Muir K, Bornstein N, Ozturk S, O'Donnell M, Mundl H, Pater C, Weitz J, Peacock WF, Swaminathan B, Kirsch B, Berkowitz SD, Peters G, Pare G, Themeles E, Shoamanesh A, Connolly SJ, Hart RG, Mackey A, Camden M, Verreault S

Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial.

Journal Article

J Stroke Cerebrovasc Dis, 27 (6), 2018.

Abstract | Links:

Hart RG, Sharma M, Mundl H, Kasner SE, Bangdiwala SI, Berkowitz SD, Swaminathan B, Lavados P, Wang Y, Davalos A, Shamalov N, Mikulik R, Cunha L, Lindgren A, Arauz A, Lang W, Czlonkowska A, Eckstein J, Gagliardi RJ, Amarenco P, Ameriso SF, Tatlisumak T, Veltkamp R, Hankey GJ, Toni D, Bereczki D, Uchiyama S, Ntaios G, Yoon BW, Brouns R, Endres M, Muir KW, Bornstein N, Ozturk S, O'Donnell MJ, De Vries Basson MM, Pare G, Pater C, Kirsch B, Sheridan P, Peters G, Weitz JI, Peacock WF, Shoamanesh A, Benavente OR, Joyner C, Themeles E, Connolly SJ, Mackey A, Camden M, Verreault S, Anderson DC, DeMets DL, Kaste M, Norrving B, Wyse DG, Alet M, Allende G, Beinlich A, Berrios W, Bruera G, Castro D, Chialvo L, Claverie S, Contardo L, Couto J, Deganutto R, Diaz R, Dossi D, Esnaola M, Falco M, Fernandez Pirrone P, Ferrari J, Firstenfeld A, Galli Giqueauk E, Gilli M, Gonzalez L, Gonzalez Toledo M, Grecco M, Halac B, Hawkes M, Ioli P, Jure L, Klein F, Lepera S, Lujan S, Mackinnon F, Marroquin M, Martin J, Parisi V, Perez Leguizamon P, Persi G, Povedano P, Pujol Lereis V, Radrizzani L, Reich E, Repetto M, Rodriguez Lucci F, Romano M, Saredo G, Schneider M, Simonsini C, Sumay G, Thomson A, Toledo W, Torres C, Vila A, Abdul Rasheed N, Bailey P, Blacker D, Carcel C, Clissold B, Delcourt C, Field D, Gangadharan S, Ghia D, Kleinig T, Leyden J, Ly J, Ma H, Mishra S, Moey A, Musuka T, Pepper E, Phan T, Sabet A, Saw J, Singh B, Tryambake D, Tu H, Wijeratne T, Wong A, Augustin S, Esterbauer M, Garnauf M, Gasiorek K, Gasser S, Gaugg M, Greisenegger S, Harrasser M, Heine M, Huber B, Joachim B, Kapeller P, Krebs S, Kreuzpointer R, Kunzmann J, Lechner H, Lohninger B, Luschin G, Macher S, Marko M, Matosevic B, Mayr A, Mismas A, Mitrovic N, Mutzenbach J, Oberndorfer S, Obmann S, Raffelsberger T, Roesler C, Salletmayr T, Serles W, Stadler K, Tinchon A, Tolino M, Verocai V, Vigl M, Voglsperger B, Weber J, Werner P, Windt J, Winkler A, Wurzinger H, Zelenka I, Cras P, Crols R, De Keyser J, De Klippel N, De Pauw A, De Smedt A, Dhollander I, Hermans S, Ligot N, Maqueda V, Maqueda Maqueda V, Naeije G, Seynaeve L, Soors P, Van Daele W, Vanacker P, Vanderschueren G, Willems C, Yperzeele L, Avelar W, Bacellar A, Batista C, Bazan R, Braga G, Cardoso F, Dagnino M, Fabio S, Ferreira Junior G, Freitas G

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source.

Journal Article

N Engl J Med, 378 (23), 2018.

Abstract | Links:

Khandhar SJ, Bowling MR, Flandes J, Gildea TR, Hood KL, Krimsky WS, Minnich DJ, Murgu SD, Pritchett M, Toloza EM, Wahidi MM, Wolvers JJ, Folch EE, Mackey A, Camden M, Verreault S

Electromagnetic navigation bronchoscopy to access lung lesions in 1,000 subjects: first results of the prospective, multicenter NAVIGATE study.

Journal Article

BMC Pulm Med, 17 (1), 2017.

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Masson-Roy J, Savard M, Mackey A

Carotid Cavernous Fistula in a Patient with Type IV Ehlers-Danlos Syndrome.

Journal Article

Can J Neurol Sci, 44 (4), 2017.

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Michelson KN, Frader J, Sorce L, Clayman ML, Persell SD, Fragen P, Ciolino JD, Campbell LC, Arenson M, Aniciete DY, Brown ML, Ali FN, White D, Mackey A, Camden M, Verreault S

The Process and Impact of Stakeholder Engagement in Developing a Pediatric Intensive Care Unit Communication and Decision-Making Intervention.

Journal Article

J Patient Exp, 3 (4), 2016.

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Active projects

  • Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2), from 2015-03-01 to 2022-12-25
Data provided by the Université Laval research projects registery