Dr. Adnane Sellam joined Laval University in August 2013 as an assistant professor at the School of Medicine (Department of Microbiology-Infectious Disease and Immunology) and new member of the CHU de Québec research center and its vibrant community of researchers. As a principal investigator, Dr Sellam is affiliated to the Centre de Recherche en Infectiologie (CRI-CHUL) and the centre de recherche en données massives de l’Université Laval (CRDM-UL). Dr Sellam held a Ph.D. from University of Angers (France) and undertook two productive postdoctoral trainings at Université de Montréal and University McGill/NRC Canada. Dr. Sellam is an expert on Systems biology and genomics, applied to fungal pathogens. His research has been funded by different recognized provincial (CQDM, FRQS, CHUQ foundation, Merck-U Laval) and federal (NSERC, CFI) funding organisms.

Candida albicans is an opportunistic pathogen responsible for various non-life-threatening infections, such as oral thrush and vaginitis. This pathogen is also a major cause of morbidity and mortality in bloodstream infections, especially in immunosuppressed individuals. The arsenal of clinically active antifungal compounds is limited, because of the eukaryotic nature of this yeast, which makes it like its human host. In addition, many cases of clinical resistance to all anti-Candida drugs have been reported. Currently, the pipeline of pharmaceutical companies for new drugs targeting C. albicans infections is completely dry. Thus, discovery of new drugs is of utmost urgency to fight C. albicans infections. The purpose of Dr. Sellam’s research is to gain a deep knowledge on mechanisms that control the virulence of C. albicans. This will lead to identification of proteins or biological processes that are required for the establishment of the infection. Screens of chemical libraries will identify bioactive molecules that inhibit these proteins, and consequently limit the infections.

The main objective of my research program is to decipher C. albicans regulatory circuits that control adaptation to hypoxia and cell size homeostasis. These biological processes are both intimately linked to C. albicans virulence. Dr. Sellam’s team is also screening different chemical libraries to find small molecules inhibiting filamentation and biofilm formation, which are key manifestations of C. albicans pathogenicity.

CHUL
2705, boulevard Laurier
RC-709
Québec, Québec
Canada G1V 4G2
36 entries « 1 of 8 »

Garcia C, Burgain A, Chaillot J, Pic E, Khemiri I, Sellam A

A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion.

Journal Article

Sci Rep, 8 (1), pp. 11559, 2018, ISSN: 2045-2322.

Abstract | Links:

Pic E, Burgain A, Sellam A

Repurposing the anthelminthic salicylanilide oxyclozanide against susceptible and clinical resistant Candida albicans strains.

Journal Article

Med Mycol, 2018, ISSN: 1369-3786.

Abstract | Links:

Omar RF, Guilbert E, Gallo MF, Leboeuf M, Boissinot M, Sellam A, Trottier S, Kobinger G, Bergeron MG

Empowerment of Women: Closing the Medical Technologies Gender Gap.

Journal Article

J Obstet Gynaecol Can, 40 (1), pp. 78-83, 2018, ISSN: 1701-2163.

| Links:

Tebbji F, Chen Y, Sellam A, Whiteway M

The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans.

Journal Article

mSphere, 2 (6), 2017, ISSN: 2379-5042.

Abstract | Links:

Garcia C, Tebbji F, Daigneault M, Liu NN, Kohler JR, Allen-Vercoe E, Sellam A

The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway.

Journal Article

mSphere, 2 (6), 2017, ISSN: 2379-5042.

Abstract | Links:

36 entries « 1 of 8 »

Active projects

  • Centre de recherche en données massives, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2016-06-07 to 2021-06-06
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Étude du déterminisme du pouvoir pathogène de la levure pathogène Candida albicans par des approches de génomiques et de biologie des systèmes., Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2015-07-01 to 2019-06-30
  • Systems biology of the hypoxic adaptation., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2014-04-01 to 2019-03-31
  • The transcriptional circuitry controlling the metabolic flexibility and host colonization under hypoxia in the human fungal pathogen Candida albicans, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2022-03-31

Recently finished projects

  • Centre de recherche en infectiologie, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
  • Centre de recherche sur les données massives (CRDM), Subvention, Institutionnel - BDR, BDR - Cas spéciaux et obligations institutionnelles, from 2015-05-01 to 2017-04-30
  • Computational and machine learning approaches to improve design and screening of high bioactivity peptides for drug discovery, Subvention, Consortium québécois sur la découverte du médicament, Concours FOCUS, from 2014-12-01 to 2017-11-30
  • Étude du déterminisme du pouvoir pathogène de la levure pathogène Candida albicans par des approches de génomiques et de biologie des systèmes., Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2015-07-01 to 2018-06-30
  • High-throughput platform for microbial phenotypic analysis and screen for antimicrobial bioactive compounds, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds des leaders John-R.-Evans (FLJR), from 2015-06-01 to 2016-12-31
  • Repurposing valproic acid, a widely prescribed anticonvulsant, to fight vulvovaginal candidiasis, Subvention, Fondation de l'Université Laval, from 2016-09-15 to 2018-09-14
Data provided by the Université Laval research projects registery