Dr. Agharazii is a nephrologist, clinician-researcher, director of the Endocrinology and Nephrology research axis of Quebec’s CRCHU. He is Professor of Medicine in the Department of Medicine at Laval University and is the Residency Program Director for Nephrology. He holds the Amgen-U. Laval Nephrology Research Chair. His work focuses on arterial stiffness, which is a consequence of vascular aging and is particularly accelerated in patients with renal failure. Arterial stiffness is the main determinant of isolated high blood pressure commonly seen in the elderly as well as in diabetic and renally impaired patients. Although there are several medications available to treat hypertension, current medications were not designed to target arterial stiffness, sometimes leading to treatment failures and causing side effects related to polypharmacy. It is therefore important to understand the mechanisms involved in the development of arterial stiffness in order to develop specific therapeutic targets.

His research program aims to elucidate the role of inflammation, bone mineral disorder and endothelin in the pathophysiology of vascular remodeling in renal failure. His research involves patient care, the use of animal models and cell cultures, and the collaboration of several researchers.

L'Hôtel-Dieu de Québec
10, rue McMahon
Québec, Québec
Canada G1R 2J6
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Azizi M, Boutouyrie P, Bissery A, Agharazii M, Verbeke F, Stern N, Bura-Riviere A, Laurent S, Alhenc-Gelas F, Jeunemaitre X

Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans.

Journal Article

J Clin Invest, 115 (3), pp. 780-7, 2005, ISSN: 0021-9738.

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Active projects

  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2024-09-30
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE), Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-04-01 to 2025-03-31
  • Impact du travail sur la maladie rénale, Subvention, Fondation de l'Université Laval, from 2017-05-01 to 2021-04-30
  • Mécanismes de la rigidité aortique en insuffisance rénale chez l'humain, Subvention, Fondation de l'Université Laval, from 2018-06-01 to 2021-05-31
  • Non-invasive measurement of arterial stiffness of microcirculation in humans: an integrated approach, Subvention, Fondation de l'Université Laval, from 2020-01-20 to 2021-01-19

Recently finished projects

  • Chaire de recherche en néphrologie Amgen, Subvention, Fondation de l'Université Laval, from 2015-01-01 to 2019-12-31
  • Optimisation et évaluation des patients en insuffisance rénale chronique , Subvention, Fondation du CHU de Québec, from 2019-10-10 to 2020-10-09
  • Progression des altérations structurelles et biomécaniques des artères centrales et périphériques en insuffisance rénale chronique et prix Louis Belleau, Subvention, Fondation de l'Université Laval, from 2016-04-01 to 2020-12-31
Data provided by the Université Laval research projects registery