Dr. Agharazii is a nephrologist, clinician-researcher, director of the Endocrinology and Nephrology research axis of Quebec’s CRCHU. He is Professor of Medicine in the Department of Medicine at Laval University and is the Residency Program Director for Nephrology. He holds the Amgen-U. Laval Nephrology Research Chair. His work focuses on arterial stiffness, which is a consequence of vascular aging and is particularly accelerated in patients with renal failure. Arterial stiffness is the main determinant of isolated high blood pressure commonly seen in the elderly as well as in diabetic and renally impaired patients. Although there are several medications available to treat hypertension, current medications were not designed to target arterial stiffness, sometimes leading to treatment failures and causing side effects related to polypharmacy. It is therefore important to understand the mechanisms involved in the development of arterial stiffness in order to develop specific therapeutic targets.

His research program aims to elucidate the role of inflammation, bone mineral disorder and endothelin in the pathophysiology of vascular remodeling in renal failure. His research involves patient care, the use of animal models and cell cultures, and the collaboration of several researchers.

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Québec, Québec
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Fortier C, Obeid H, Paré M, Garneau CA, Sidibé A, Boutouyrie P, Agharazii M

Changes in arterial stiffness indices during a single haemodialysis session in end-stage renal disease population: a systematic review and meta-analysis protocol.

Journal Article

BMJ Open, 11 (9), 2021.

Abstract | Links:

Boyer A, Begin Y, Dupont J, Rousseau-Gagnon M, Fernandez N, Demian M, Simonyan D, Agharazii M, Mac-Way F

Health literacy level in a various nephrology population from Québec: predialysis clinic, in-centre hemodialysis and home dialysis; a transversal monocentric observational study.

Journal Article

BMC Nephrol, 22 (1), 2021.

Abstract | Links:

Kowalski C, Yang K, Charron T, Doucet M, Hatem R, Kouz R, Palisaitis D, Schampaert E, Terriault P, Tessier P, Agharazii M, Goupil R

Inaccuracy of brachial blood pressure and its potential impact on treatment and aortic blood pressure estimation.

Journal Article

J Hypertens, 2021.

Abstract | Links:

Parent-Roberge H, Deshayes TA, Fortier C, Marquis K, Lacharite-Lemieux C, Rodrigue C, Dionne IJ, Agharazii M, Godin M, Riesco E

Feasibility of an Intradialytic Combined Exercise Program Targeting Older Adults With End-Stage Renal Disease.

Journal Article

J Aging Phys Act, 2021.

Abstract | Links:

Obeid H, Fortier C, Garneau CA, Pare M, Boutouyrie P, Bruno RM, Khettab H, Goupil R, Agharazii M

Radial-digital pulse wave velocity: a noninvasive method for assessing stiffness of small conduit arteries.

Journal Article

Am J Physiol Heart Circ Physiol, 320 (4), 2021.

Abstract | Links:

Agharazii M

Coagulation anomalies, endothelial dysfunction, and aortic stiffness.

Journal Article

Kidney Int, 99 (5), 2021.

Abstract | Links:

Lamarche F, Agharazii M, Madore F, Goupil R

Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure: A Prospective Study.

Journal Article

Hypertension, 77 (2), 2021.

Abstract | Links:

Dupuis ME, Nadeau-Fredette AC, Madore F, Agharazii M, Goupil R

Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals.

Journal Article

JAMA Netw Open, 3 (4), 2020.

Abstract | Links:

Rodriguez RA, Spence M, Hae R, Agharazii M, Burns KD

Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis.

Journal Article

Can J Kidney Health Dis, 7 , 2020.

Abstract | Links:

Cote G, Asselin-Thompstone L, Mac-Way F, Rene de Cotret P, Lacroix C, Desmeules S, Agharazii M

Sodium and urea excretion as determinants of urine output in autosomal dominant polycystic kidney disease patients on V2 receptor antagonists: impact of dietary intervention.

Journal Article

Int Urol Nephrol, 52 (2), 2020.

Abstract | Links:

77 entries « 1 of 8 »
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Active projects

  • Accelerated CKD-related vascular calcification: Role of thiazide-type, thiazide-like and loop diuretics, from 2020-10-01 to 2022-09-30
  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, from 2019-10-01 to 2024-09-30
  • Characterizing Cardiovascular Outcomes in Subclinical Primary Aldosteronism, from 2021-04-01 to 2024-03-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2022-05-31
  • Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE), from 2020-04-01 to 2025-03-31
  • Identifying low bone turnover disease in chronic kidney disease in order to guide anti-fracture therapy, from 2020-10-01 to 2025-09-30
  • Mécanismes de la rigidité aortique en insuffisance rénale chez l'humain, from 2018-06-01 to 2022-04-30
  • Non-invasive measurement of arterial stiffness of microcirculation in humans: an integrated approach, from 2020-01-20 to 2022-04-30
  • Traiter l’os pour prévenir l’hypertension et les maladies cardiovasculaires chez les femmes ménopausées., from 2021-05-01 to 2022-04-30

Recently finished projects

  • Chaire de recherche en néphrologie Amgen, from 2015-01-01 to 2019-12-31
  • Impact du travail sur la maladie rénale, from 2017-05-01 to 2021-04-30
  • Optimisation et évaluation des patients en insuffisance rénale chronique , from 2019-10-10 to 2020-10-09
  • Progression des altérations structurelles et biomécaniques des artères centrales et périphériques en insuffisance rénale chronique et prix Louis Belleau, from 2016-04-01 to 2020-12-31
Data provided by the Université Laval research projects registery