Dr. Agharazii is a nephrologist, clinician-researcher, director of the Endocrinology and Nephrology research axis of Quebec’s CRCHU. He is Professor of Medicine in the Department of Medicine at Laval University and is the Residency Program Director for Nephrology. He holds the Amgen-U. Laval Nephrology Research Chair. His work focuses on arterial stiffness, which is a consequence of vascular aging and is particularly accelerated in patients with renal failure. Arterial stiffness is the main determinant of isolated high blood pressure commonly seen in the elderly as well as in diabetic and renally impaired patients. Although there are several medications available to treat hypertension, current medications were not designed to target arterial stiffness, sometimes leading to treatment failures and causing side effects related to polypharmacy. It is therefore important to understand the mechanisms involved in the development of arterial stiffness in order to develop specific therapeutic targets.

His research program aims to elucidate the role of inflammation, bone mineral disorder and endothelin in the pathophysiology of vascular remodeling in renal failure. His research involves patient care, the use of animal models and cell cultures, and the collaboration of several researchers.

L'Hôtel-Dieu de Québec
10, rue McMahon
0886
Québec, Québec
Canada G1R 2J6
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Dupuis ME, Nadeau-Fredette AC, Madore F, Agharazii M, Goupil R

Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals.

Journal Article

JAMA Netw Open, 3 (4), pp. e202377, 2020, ISSN: 2574-3805.

Abstract | Links:

Pare M, Goupil R, Fortier C, Mac-Way F, Madore F, Marquis K, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Agharazii M

Determinants of Increased Central Excess Pressure in Dialysis: Role of Dialysis Modality and Arteriovenous Fistula.

Journal Article

Am J Hypertens, 33 (2), pp. 137-145, 2020, ISSN: 0895-7061.

Abstract | Links:

Cote G, Asselin-Thompstone L, Mac-Way F, Rene de Cotret P, Lacroix C, Desmeules S, Agharazii M

Sodium and urea excretion as determinants of urine output in autosomal dominant polycystic kidney disease patients on V2 receptor antagonists: impact of dietary intervention.

Journal Article

Int Urol Nephrol, 52 (2), pp. 343-349, 2020, ISSN: 0301-1623.

Abstract | Links:

Rodriguez RA, Spence M, Hae R, Agharazii M, Burns KD

Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis.

Journal Article

Can J Kidney Health Dis, 7 , pp. 2054358120906974, 2020, ISSN: 2054-3581.

Abstract | Links:

Rodriguez RA, Hae R, Spence M, Shea B, Agharazii M, Burns KD

A Systematic Review and Meta-analysis of Nonpharmacologic-based Interventions for Aortic Stiffness in End-Stage Renal Disease.

Journal Article

Kidney Int Rep, 4 (8), pp. 1109-1121, 2019, ISSN: 2468-0249.

Abstract | Links:

Fortier C, Cote G, Mac-Way F, Goupil R, Desbiens LC, Desjardins MP, Marquis K, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Agharazii M

Prognostic Value of Carotid and Radial Artery Reservoir-Wave Parameters in End-Stage Renal Disease.

Journal Article

J Am Heart Assoc, 8 (13), pp. e012314, 2019, ISSN: 2047-9980.

Abstract | Links:

Bisson SK, Ung RV, Picard S, Valade D, Agharazii M, Lariviere R, Mac-Way F

High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats.

Journal Article

J Bone Miner Metab, 37 (2), pp. 212-223, 2019, ISSN: 0914-8779.

Abstract | Links:

Leblanc ME, Auclair A, Leclerc J, Bussieres J, Agharazii M, Hould FS, Marceau S, Brassard P, Godbout C, Grenier A, Cloutier L, Poirier P

Blood Pressure Measurement in Severely Obese Patients: Validation of the Forearm Approach in Different Arm Positions.

Journal Article

Am J Hypertens, 32 (2), pp. 175-185, 2019, ISSN: 0895-7061.

Abstract | Links:

Desjardins MP, Sidibe A, Fortier C, Mac-Way F, De Serres S, Lariviere R, Spronck B, Goupil R, Agharazii M

Impact of kidney transplantation on aortic stiffness and aortic stiffness index β0.

Journal Article

J Hypertens, 37 (7), pp. 1521-1528, 2019, ISSN: 0263-6352.

Abstract | Links:

Desbiens LC, Sidibe A, Ung RV, Fortier C, Munger M, Wang YP, Bisson SK, Marquis K, Agharazii M, Mac-Way F

FGF23-klotho axis, bone fractures, and arterial stiffness in dialysis: a case-control study.

Journal Article

Osteoporos Int, 29 (10), pp. 2345-2353, 2018, ISSN: 0937-941X.

Abstract | Links:

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Active projects

  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2024-09-30
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Early Prediction of preeclampsia Using arteriaL Stiffness in high-risk prEgnancies; a multinational study (PULSE), Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-04-01 to 2025-03-31
  • Impact du travail sur la maladie rénale, Subvention, Fondation de l'Université Laval, from 2017-05-01 to 2021-04-30
  • Mécanismes de la rigidité aortique en insuffisance rénale chez l'humain, Subvention, Fondation de l'Université Laval, from 2018-06-01 to 2021-05-31
  • Non-invasive measurement of arterial stiffness of microcirculation in humans: an integrated approach, Subvention, Fondation de l'Université Laval, from 2020-01-20 to 2021-01-19
  • Optimisation et évaluation des patients en insuffisance rénale chronique , Subvention, Fondation du CHU de Québec, from 2019-10-10 to 2020-10-09
  • Progression des altérations structurelles et biomécaniques des artères centrales et périphériques en insuffisance rénale chronique et prix Louis Belleau, Subvention, Fondation de l'Université Laval, from 2016-04-01 to 2020-12-31

Recently finished projects

  • Chaire de recherche en néphrologie Amgen, Subvention, Fondation de l'Université Laval, from 2015-01-01 to 2019-12-31
Data provided by the Université Laval research projects registery