Dr. Agharazii is a nephrologist, clinician-researcher, assistant director of the Endocrinology and Nephrology research axis of Quebec’s CRCHU. He is Professor of Medicine in the Department of Medicine at Laval University and is the Residency Program Director for Nephrology. He holds the Amgen-U. Laval Nephrology Research Chair. His work focuses on arterial stiffness, which is a consequence of vascular aging and is particularly accelerated in patients with renal failure. Arterial stiffness is the main determinant of isolated high blood pressure commonly seen in the elderly as well as in diabetic and renally impaired patients. Although there are several medications available to treat hypertension, current medications were not designed to target arterial stiffness, sometimes leading to treatment failures and causing side effects related to polypharmacy. It is therefore important to understand the mechanisms involved in the development of arterial stiffness in order to develop specific therapeutic targets.

His research program aims to elucidate the role of inflammation, bone mineral disorder and endothelin in the pathophysiology of vascular remodeling in renal failure. His research involves patient care, the use of animal models and cell cultures, and the collaboration of several researchers.

L'Hôtel-Dieu de Québec
10, rue McMahon
0886
Québec, Québec
Canada G1R 2J6
67 entries « 1 of 7 »

Pare M, Goupil R, Fortier C, Mac-Way F, Madore F, Marquis K, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Agharazii M

Determinants of increased central excess pressure in dialysis: role of dialysis modality and arteriovenous fistula.

Journal Article

Am J Hypertens, 2019, ISSN: 0895-7061.

Abstract | Links:

Rodriguez RA, Hae R, Spence M, Shea B, Agharazii M, Burns KD

A Systematic Review and Meta-analysis of Nonpharmacologic-based Interventions for Aortic Stiffness in End-Stage Renal Disease.

Journal Article

Kidney Int Rep, 4 (8), pp. 1109-1121, 2019, ISSN: 2468-0249.

Abstract | Links:

Fortier C, Cote G, Mac-Way F, Goupil R, Desbiens LC, Desjardins MP, Marquis K, Hametner B, Wassertheurer S, Schultz MG, Sharman JE, Agharazii M

Prognostic Value of Carotid and Radial Artery Reservoir-Wave Parameters in End-Stage Renal Disease.

Journal Article

J Am Heart Assoc, 8 (13), pp. e012314, 2019, ISSN: 2047-9980.

Abstract | Links:

Desjardins MP, Sidibe A, Fortier C, Mac-Way F, De Serres S, Lariviere R, Spronck B, Goupil R, Agharazii M

Impact of kidney transplantation on aortic stiffness and aortic stiffness index β0.

Journal Article

J Hypertens, 37 (7), pp. 1521-1528, 2019, ISSN: 0263-6352.

Abstract | Links:

Bisson SK, Ung RV, Picard S, Valade D, Agharazii M, Lariviere R, Mac-Way F

High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats.

Journal Article

J Bone Miner Metab, 37 (2), pp. 212-223, 2019, ISSN: 0914-8779.

Abstract | Links:

Leblanc ME, Auclair A, Leclerc J, Bussieres J, Agharazii M, Hould FS, Marceau S, Brassard P, Godbout C, Grenier A, Cloutier L, Poirier P

Blood Pressure Measurement in Severely Obese Patients: Validation of the Forearm Approach in Different Arm Positions.

Journal Article

Am J Hypertens, 32 (2), pp. 175-185, 2019, ISSN: 0895-7061.

Abstract | Links:

Desbiens LC, Sidibe A, Ung RV, Fortier C, Munger M, Wang YP, Bisson SK, Marquis K, Agharazii M, Mac-Way F

FGF23-klotho axis, bone fractures, and arterial stiffness in dialysis: a case-control study.

Journal Article

Osteoporos Int, 29 (10), pp. 2345-2353, 2018, ISSN: 0937-941X.

Abstract | Links:

Lepeytre F, Lavoie PL, Troyanov S, Madore F, Agharazii M, Goupil R

Uric acid association with pulsatile and steady components of central and peripheral blood pressures.

Journal Article

J Hypertens, 36 (3), pp. 495-501, 2018, ISSN: 0263-6352.

Abstract | Links:

Desy O, Beland S, Vallin P, Riopel J, Latulippe E, Najafian N, Chandraker A, Agharazii M, Batal I, De Serres SA

IL-6 production by monocytes is associated with graft function decline in patients with borderline changes suspicious for acute T-cell-mediated rejection: a pilot study.

Journal Article

Transpl Int, 31 (1), pp. 92-101, 2018, ISSN: 0934-0874.

Abstract | Links:

Desjardins MP, Sidibe A, Fortier C, Mac-Way F, Marquis K, De Serres S, Lariviere R, Agharazii M

Association of interleukin-6 with aortic stiffness in end-stage renal disease.

Journal Article

J Am Soc Hypertens, 12 (1), pp. 5-13, 2018, ISSN: 1933-1711.

Abstract | Links:

67 entries « 1 of 7 »
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Active projects

  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2024-09-30
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Chaire de recherche en néphrologie Amgen, Subvention, Fondation de l'Université Laval, from 2015-01-01 to 2019-12-31
  • Chaire de recherche en néphrologie Amgen, Subvention, Fondation de l'Université Laval, Chaires de recherche sans organismes subventionnaires, from 2014-04-01 to 2099-05-31
  • Mécanismes de la rigidité aortique en insuffisance rénale chez l'humain, Subvention, Fondation de l'Université Laval, from 2018-06-01 to 2020-05-31
  • Progression des altérations structurelles et biomécaniques des artères centrales et périphériques en insuffisance rénale chronique et prix Louis Belleau, Subvention, Fondation de l'Université Laval, from 2016-04-01 to 2020-12-31

Recently finished projects

  • (FRSQ 83757)Le développement d'une stratégie d'activité physique adaptée à la clientèle dialysée, Subvention, Fondation du CHU de Québec, from 2018-06-08 to 2019-03-31
  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
  • Impact du travail sur la maladie rénale, Subvention, Fondation de l'Université Laval, from 2017-05-01 to 2019-04-30
  • Mechanisms of chronic kidney disease-related vascular calcification. role of the endothelin system., Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2016-07-01 to 2018-06-30
Data provided by the Université Laval research projects registery