Dr. Agharazii is a nephrologist, clinician-researcher, assistant director of the Endocrinology and Nephrology research axis of Quebec’s CRCHU. He is Professor of Medicine in the Department of Medicine at Laval University and is the Residency Program Director for Nephrology. He holds the Amgen-U. Laval Nephrology Research Chair. His work focuses on arterial stiffness, which is a consequence of vascular aging and is particularly accelerated in patients with renal failure. Arterial stiffness is the main determinant of isolated high blood pressure commonly seen in the elderly as well as in diabetic and renally impaired patients. Although there are several medications available to treat hypertension, current medications were not designed to target arterial stiffness, sometimes leading to treatment failures and causing side effects related to polypharmacy. It is therefore important to understand the mechanisms involved in the development of arterial stiffness in order to develop specific therapeutic targets.

His research program aims to elucidate the role of inflammation, bone mineral disorder and endothelin in the pathophysiology of vascular remodeling in renal failure. His research involves patient care, the use of animal models and cell cultures, and the collaboration of several researchers.

L'Hôtel-Dieu de Québec
10, rue McMahon
Local 0886
Québec, Québec
Canada G1R 2J6
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Desbiens LC, Sidibe A, Ung RV, Fortier C, Munger M, Wang YP, Bisson SK, Marquis K, Agharazii M, Mac-Way F

FGF23-klotho axis, bone fractures, and arterial stiffness in dialysis: a case-control study.

Journal Article

Osteoporos Int, 2018, ISSN: 0937-941X.

Abstract | Links:

Tripepi G, Agharazii M, Pannier B, D'Arrigo G, Mallamaci F, Zoccali C, London G

Pulse Wave Velocity and Prognosis in End-Stage Kidney Disease.

Journal Article

Hypertension, 71 (6), pp. 1126-1132, 2018, ISSN: 0194-911X.

Abstract | Links:

Bisson SK, Ung RV, Picard S, Valade D, Agharazii M, Lariviere R, Mac-Way F

High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats.

Journal Article

J Bone Miner Metab, 2018, ISSN: 0914-8779.

Abstract | Links:

Lepeytre F, Lavoie PL, Troyanov S, Madore F, Agharazii M, Goupil R

Uric acid association with pulsatile and steady components of central and peripheral blood pressures.

Journal Article

J Hypertens, 36 (3), pp. 495-501, 2018, ISSN: 0263-6352.

Abstract | Links:

Lamarche F, Agharazii M, Nadeau-Fredette AC, Madore F, Goupil R

Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein Cholesterol: A Mediation Analysis.

Journal Article

Hypertension, 71 (3), pp. 415-421, 2018, ISSN: 0194-911X.

Abstract | Links:

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Active projects

  • Arterial calcification and kidney disease: role of inflammation (Chaire de recherche en néphrologie Amgen), Subvention, Fondation de l'Université Laval, Chaires de recherche sans organismes subventionnaires, from 2014-04-01 to 2099-05-31
  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Chaire de recherche en néphrologie Amgen, Subvention, Fondation de l'Université Laval, from 2015-01-01 to 2019-12-31
  • Impact du travail sur la maladie rénale, Subvention, Fondation de l'Université Laval, from 2017-05-01 to 2019-04-30
  • Progression des altérations structurelles et biomécaniques des artères centrales et périphériques en insuffisance rénale chronique et prix Louis Belleau, Subvention, Fondation de l'Université Laval, from 2016-04-01 to 2018-09-30

Recently finished projects

  • (FRSQ 75008) Acquisition d'un appareil pour mesurer la rigidité artérielle chez les patients dialysés, Subvention, Fondation du CHU de Québec, from 2016-06-06 to 2017-06-05
  • Mechanisms of chronic kidney disease-related vascular calcification. role of the endothelin system., Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2016-07-01 to 2018-06-30
  • Metabolic bone research unit in chronic kidney disease, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds des leaders John-R.-Evans (FLJR), from 2016-05-01 to 2017-12-31
Data provided by the Université Laval research projects registery