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Wednesday 22 Nov

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Jean Sévigny

Formation
PhD Biologie

No active offer

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Principal area
Infectious and immune diseases
Address
Centre Hospitalier de l'Université Laval (CHUL)
2705, boulevard Laurier, T-1-49
Québec (Québec)
CANADA G1V 4G2

Phone
+1 418-525-4444, poste 46319
Fax
+1 418-654-2765
Email
jean.sevigny@crchudequebec.ulaval.ca
Other Web Site:

Distribution of anti-ectonucleotidase antibodies:

http://ectonucleotidases-ab.com

Research team

Research Assistant
Julie Pelletier

PhD Students
Mabrouka Salem
Hervé Agonsanou

MSc Student
Romuald Babou

Trainees
Alexis Kapanga

 

Research project(s) recognized by Université Laval (in French)

Other active research project(s)

No active project

Recent publications (see all publication from this researcher)

Pelletier J, Salem M, Lecka J, Fausther M, Bigonnesse F, Sevigny J. Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8. Frontiers in pharmacology,  2017. 8: 115
Kuhrt D, Ejaz SA, Afzal S, Khan SU, Lecka J, Sevigny J, Ehlers P, Spannenberg A, Iqbal J, Langer P. Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors. European journal of medicinal chemistry,  2017. 138: 816-829
Mitrovic N, Zaric M, Drakulic D, Martinovic J, Sevigny J, Stanojlovic M, Nedeljkovic N, Grkovic I. Erratum to: 17beta-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes. Journal of molecular neuroscience : MN,  2017. 61: 423-424
Ejaz SA, Saeed A, Siddique MN, Nisa ZU, Khan S, Lecka J, Sevigny J, Iqbal J. Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors. Bioorganic chemistry,  2017. 70: 229-236
Channar PA, Shah SJ, Hassan S, Nisa ZU, Lecka J, Sevigny J, Bajorath J, Saeed A, Iqbal J. Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase. Chemical biology & drug design,  2017. 89: 365-370
Feldbrugge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Muller CE, Sevigny J, Robson SC, Jiang ZG. Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. Journal of Crohn's & colitis,  2017. 11: 1113-1123
Bastos MS, Tremblay A, Agripino JM, Rabelo IL, Barreto LP, Pelletier J, Lecka J, Silva-Junior A, Bressan GC, Almeida MR, Sevigny J, Fietto JL. The expression of NTPDase1 and -2 of Leishmania infantum chagasi in bacterial and mammalian cells: Comparative expression, refolding and nucleotidase characterization. Protein expression and purification,  2017. 131: 60-69
Mitrovic N, Zaric M, Drakulic D, Martinovic J, Sevigny J, Stanojlovic M, Nedeljkovic N, Grkovic I. 17beta-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes. Journal of molecular neuroscience : MN,  2017. 61: 412-422
Barros-Barbosa AR, Ferreirinha F, Oliveira A, Mendes M, Lobo MG, Santos A, Rangel R, Pelletier J, Sevigny J, Cordeiro JM, Correia-de-Sa P. Adenosine A2A receptor and ecto-5'-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE). Purinergic signalling,  2016. 12: 719-734
Ausekle E, Ejaz SA, Khan SU, Ehlers P, Villinger A, Lecka J, Sevigny J, Iqbal J, Langer P. New one-pot synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation: potent inhibitors of nucleotide pyrophosphatase-1 and -3. Organic & biomolecular chemistry,  2016. 14: 11402-11414
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