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Martin Pelletier

Formation
B.Sc. Biochemistry, Université du Québec à Montréal, Montréal, Canada

M.Sc. Experimental Health Sciences, INRS-Institut Armand-Frappier, Laval, Canada

Ph.D. Virology-Immunology, INRS-Institut Armand-Frappier, Laval, Canada

Postdoctoral fellowship, University of Verona, Verona, Italy

Postdoctoral fellowship, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS)/National Institutes of Health (NIH), Bethesda, USA

No active offer

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Principal area
Infectious and immune diseases
Address
Centre Hospitalier de l'Université Laval (CHUL)
2705, boulevard Laurier, T-1-49
Québec (Québec)
CANADA G1V 4G2

Phone
+1 418-525-4444, poste 46166
Fax
Email
Martin.Pelletier@crchudequebec.ulaval.ca

 

Immune cells require energy for housekeeping functions as well as for specific immune functions, and alterations in bioenergetics are often associated with diseases such as diabetes and cancer. Inflammation is involved in the pathogenesis of various diseases, as it puts the whole body under metabolic stress, driving inflammatory symptoms and causing morbidity. My research program aims at understanding the role of energy metabolism during the inflammatory response, more precisely in the pathophysiology of inflammatory arthritis. We use different approches in cellular and molecular biology to examine immune cells' bioenergetics from patients and mouse models. Overall, this work will bring important information on the molecular mechanisms that regulate immune cells' energy metabolism as well as the influence of the inflammatory environment on this important biochemical process.

Research team

  Asmaa Lachhad, PhD candidate

Research project(s) recognized by Université Laval (in French)

Other active research project(s)

No active project

Recent publications (see all publication from this researcher)

Laouedj M, Tardif MR, Gil L, Raquil MA, Lachaab A, Pelletier M, Tessier PA, Barabe F. S100A9 induces differentiation of acute myeloid leukemia cells through TLR4. Blood,  2017. Epub
Rousseau LS, Pare G, Lachhab A, Naccache PH, Marceau F, Tessier P, Pelletier M, Fernandes M. S100A9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals. Journal of leukocyte biology,  2017. Epub
Brehm A, Liu Y, Sheikh A, Marrero B, Omoyinmi E, Zhou Q, Montealegre G, Biancotto A, Reinhardt A, de Jesus AA, Pelletier M, Tsai WL, Remmers EF, Kardava L, Hill S, Kim H, Lachmann HJ, Megarbane A, Chae JJ, Brady J, Castillo RD, Brown D, Casano AV, Gao L, Chapelle D, Huang Y, Stone D, Chen Y, Sotzny F, Lee CC, Kastner DL, Torrelo A, Zlotogorski A, Moir S, Gadina M, McCoy P, Wesley R, Rother KI, Hildebrand PW, Brogan P, Kruger E, Aksentijevich I, Goldbach-Mansky R. Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. The Journal of clinical investigation,  2016. 126: 795
Zilberman-Rudenko J, Shawver LM, Wessel AW, Luo Y, Pelletier M, Tsai WL, Lee Y, Vonortas S, Cheng L, Ashwell JD, Orange JS, Siegel RM, Hanson EP. Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-kappaB activation and autoinflammatory disease. Proceedings of the National Academy of Sciences of the United States of America,  2016. 113: 1612-7
Wilhelm C, Harrison OJ, Schmitt V, Pelletier M, Spencer SP, Urban JF Jr, Ploch M, Ramalingam TR, Siegel RM, Belkaid Y. Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection. The Journal of experimental medicine,  2016. 213: 1409-18
Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F. Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell-Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9-Producing T Cells. Journal of immunology (Baltimore, Md. : 1950) ,  2015. 195: 5839-40
Traba J, Kwarteng-Siaw M, Okoli TC, Li J, Huffstutler RD, Bray A, Waclawiw MA, Han K, Pelletier M, Sauve AA, Siegel RM, Sack MN. Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. The Journal of clinical investigation,  2015. 125: 4592-600
Brehm A, Liu Y, Sheikh A, Marrero B, Omoyinmi E, Zhou Q, Montealegre G, Biancotto A, Reinhardt A, Almeida de Jesus A, Pelletier M, Tsai WL, Remmers EF, Kardava L, Hill S, Kim H, Lachmann HJ, Megarbane A, Chae JJ, Brady J, Castillo RD, Brown D, Casano AV, Gao L, Chapelle D, Huang Y, Stone D, Chen Y, Sotzny F, Lee CC, Kastner DL, Torrelo A, Zlotogorski A, Moir S, Gadina M, McCoy P, Wesley R, Rother K, Hildebrand PW, Brogan P, Kruger E, Aksentijevich I, Goldbach-Mansky R. Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. The Journal of clinical investigation,  2015. 125: 4196-211
Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F. The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells. Journal of immunology (Baltimore, Md. : 1950) ,  2015. 194: 3567-82
Pelletier M, Billingham LK, Ramaswamy M, Siegel RM. Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption. Methods in enzymology,  2014. 542: 125-49
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