- Principal area
- Reproduction, mother and youth health
Centre Hospitalier de l'Université Laval (CHUL)
2705, boulevard Laurier, T-3-67
CANADA G1V 4G2
- +1 418-525-4444, poste 42296 / +1 418-525-4444, poste 46252
- +1 418-654-2783
Aneuploidy is a pathological state defined by a chromosome number per cell that deviates from the normal for this organism. It occurs as a result of aberrant cell division, is the most prevalent genetic anomaly in man. Aneuploidy is the primary recognized cause of miscarriage, is connected to mental retardation in newborns. In adults, aneuploidy is a hallmark of almost all cancers and promotes tumor progression.
Our lab is interested in defining and understanding the signalling pathways and molecular mechanisms that ensure accurate cell division, and thus prevention of aneuploidy. In particular, we are interested in a small group of highly conserved kinases known as the “Spinde Assembly Checkpoint” or “SAC” kinases that collectively ensure an accurate cell division by two distinct mechanisms: 1) by ensuring accurate attachment of chromosome to the cell division apparatus 2) by delaying the division process until these accurate attachments are achieved.
Our research focuses on the following questions:
- What are the mechanisms of SAC kinase activation?
- What are the relevant substrates of the SAC kinases?
- Is the SAC differentially regulated in chromosomally stable and chromosomally instable cell lines?
We are using interdisciplinary approaches to understand both the upstream and downstream signaling events mediated by these enzymes, including mass spectrometry, high resolution microscopy, and live-cell imaging.