Dr. Lucie Jeannotte is a regular researcher at the CHU Research Centre of Québec- Université Laval, Oncology Axis, and Professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of the Faculty of Medicine at Université Laval. She is also a regular researcher at the Centre for Cancer Research at Université Laval. Her research aims at understanding the molecular mechanisms involved in the formation of the mammalian embryo with a specific interest for Hox genes. Hox genes encode transcriptional factors that play key roles in the developmental hierarchy leading to pattern formation of the embryo. Loss of Hox gene function in mice results in numerous malformations of skeleton and organs, among others, that can impair survival. The developmental origin of several diseases, including cancers, reveals how important it is to understand the mechanisms that control embryogenesis.
Function of the Hoxa5 gene in the formation of the respiratory system
Lung development implies a coordinated regulation of numerous molecules and factors. The team of Dr. Jeannotte has characterized the Hoxa5 mutant mouse line et revealed the critical and unique role of this gene in survival at birth. The loss of Hoxa5 function cause severe defects of the respiratory system that result in death of the mutants at birth. The malformations mimic pediatric congenital diseases, such as tracheal stenosis, lung hypoplasia and congenital diaphragmatic hernia as well as chronic obstructive pulmonary diseases (COPD), a major cause of death in the human population. Hoxa5 mutant mice thus provide a unique animal model to further study these pathologies. Dr. Jeannotte is interested in identifying the targets of HOXA5 transcriptional factor in the respiratory system in order to define the molecular mechanisms perturbed by the Hoxa5 mutation that underlie the phenotypes observed and may lead to future therapies.
Role of YY1 in the pathogenesis of the pleuropulmonary blastoma
The pleuropulmonary blastoma (PPB) is a rare pediatric lung tumor that arises during fetal life. It results from the progression of abnormal lung cysts to an aggressive sarcoma with poor survival. The team of Dr. Jeannotte has produced mutant mice devoid of Yy1 function in lung epithelium. This mutation causes lung cysts as those seen in PPB patients. YY1 is a transcription factor essential for embryo development and survival. YY1 expression is reduced in PPB lung tumors raising the hypothesis that the loss of Yy1 function is important for PPB pathogenesis. To determine the role and mechanisms of action of YY1 in PPB, Dr. Jeannotte aims at identifying the mechanisms of action of YY1 in lung formation in order to resolve its implication in PPB formation. These studies may reveal novel molecular targets for the design of effective and innovative therapies and better tools for the diagnosis and prognosis of this severe cancer.
In vitro interaction of Neisseria gonorrhoeae type 1 and type 4 with tissue culture cells.Journal Article
Infect Immun, 15 (2), pp. 560-7, 1977, ISSN: 0019-9567.
Stimulated release of hypothalamic growth hormone-releasing activity by morphine and pentobarbital.Journal Article
Mol Cell Endocrinol, 6 (4-5), pp. 247-52, 1977, ISSN: 0303-7207.
Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release.Journal Article
Biochem Biophys Res Commun, 74 (2), pp. 630-6, 1977, ISSN: 0006-291X.
Mechanism of action of luteinizing hormone releasing hormone and thyrotropin releasing hormone in the anterior pituitary gland and modulation of their activity by peripheral hormones.Journal Article
Adv Exp Med Biol, 87 , pp. 157-79, 1977, ISSN: 0065-2598.
Regulation of hormonereceptor levels and growth of DMBA-induced mammary tumors by RU16117 and other steroids in the ratBook Chapter
WL, McGuire; JP, Raynaud; EE, Baulieu (Ed.): Progesterone receptors in normal and neoplastic tissues, pp. 85-101, New York, Raven Press, 1977, ISBN: 0890041636.
[Modulation of lymphocyte proliferation by serum factors and lipopolysaccharide].Journal Article
Ann Immunol (Paris), 128 (1-2), pp. 33-5, 1977, ISSN: 0300-4910.
[Albumin secreting hepatocytes detected as plaque-forming cells in liquid medium].Journal Article
Ann Immunol (Paris), 128 (1-2), pp. 201-3, 1977, ISSN: 0300-4910.
Modifications métaboliques chez l'obèseJournal Article
Vie Med Can Fr, 6 , pp. 731-733, 1977, ISSN: 0301-1534.
Beta-endorphin: stimulation of growth hormone release in vivo.Journal Article
Proc Natl Acad Sci U S A, 74 (1), pp. 358-9, 1977, ISSN: 0027-8424.
High inhibitory activity of a new antiestrogen, RU 16117 (11alpha-methoxy ethinyl estradiol), on the development of dimethylbenz(a)anthracene-induced mammary tumors.Journal Article
Cancer Res, 37 (1), pp. 76-81, 1977, ISSN: 0008-5472.