Dr. Lucie Jeannotte is a regular researcher at the CHU Research Centre of Québec- Université Laval, Oncology Axis, and Professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of the Faculty of Medicine at Université Laval. She is also a regular researcher at the Centre for Cancer Research at Université Laval. Her research aims at understanding the molecular mechanisms involved in the formation of the mammalian embryo with a specific interest for Hox genes. Hox genes encode transcriptional factors that play key roles in the developmental hierarchy leading to pattern formation of the embryo. Loss of Hox gene function in mice results in numerous malformations of skeleton and organs, among others, that can impair survival. The developmental origin of several diseases, including cancers, reveals how important it is to understand the mechanisms that control embryogenesis.
Function of the Hoxa5 gene in the formation of the respiratory system
Lung development implies a coordinated regulation of numerous molecules and factors. The team of Dr. Jeannotte has characterized the Hoxa5 mutant mouse line et revealed the critical and unique role of this gene in survival at birth. The loss of Hoxa5 function cause severe defects of the respiratory system that result in death of the mutants at birth. The malformations mimic pediatric congenital diseases, such as tracheal stenosis, lung hypoplasia and congenital diaphragmatic hernia as well as chronic obstructive pulmonary diseases (COPD), a major cause of death in the human population. Hoxa5 mutant mice thus provide a unique animal model to further study these pathologies. Dr. Jeannotte is interested in identifying the targets of HOXA5 transcriptional factor in the respiratory system in order to define the molecular mechanisms perturbed by the Hoxa5 mutation that underlie the phenotypes observed and may lead to future therapies.
Role of YY1 in the pathogenesis of the pleuropulmonary blastoma
The pleuropulmonary blastoma (PPB) is a rare pediatric lung tumor that arises during fetal life. It results from the progression of abnormal lung cysts to an aggressive sarcoma with poor survival. The team of Dr. Jeannotte has produced mutant mice devoid of Yy1 function in lung epithelium. This mutation causes lung cysts as those seen in PPB patients. YY1 is a transcription factor essential for embryo development and survival. YY1 expression is reduced in PPB lung tumors raising the hypothesis that the loss of Yy1 function is important for PPB pathogenesis. To determine the role and mechanisms of action of YY1 in PPB, Dr. Jeannotte aims at identifying the mechanisms of action of YY1 in lung formation in order to resolve its implication in PPB formation. These studies may reveal novel molecular targets for the design of effective and innovative therapies and better tools for the diagnosis and prognosis of this severe cancer.
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Predictive value of quantitative ultrasound parameters in individuals with chronic kidney disease: A population-based analysis of CARTaGENE.Journal Article
Bone, 130 , pp. 115120, 2020, ISSN: 8756-3282.
Polycystic Ovary Syndrome and Metabolic Syndrome (Chapter 16)Book Chapter
PS, Zeitler; KJ, Nadeau (Ed.): Insulin Resistance : Childhood Precursors of Adult Disease, pp. 255-274, Humana Press (Springer Nature Switzerland AG), 2020, ISBN: 978-3-030-25055-3 (print) 978-3-030-25057-7 (ebook).
Brachytherapy Future Directions.Journal Article
Semin Radiat Oncol, 30 (1), pp. 94-106, 2020, ISSN: 1053-4296.
Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7.Journal Article
J Med Virol, 92 (1), pp. 4-10, 2020, ISSN: 0146-6615.
Neuroprotection and immunomodulation in the gut of parkinsonian mice with a plasmalogen precursor.Journal Article
Brain Res, 1725 , pp. 146460, 2019, ISSN: 0006-8993.
Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold.Journal Article
Eur J Med Chem, 184 , pp. 111754, 2019, ISSN: 0223-5234.
Upregulation of IL-32 Isoforms in Virologically Suppressed HIV-Infected Individuals: Potential Role in Persistent Inflammation and Transcription From Stable HIV-1 Reservoirs.Journal Article
J Acquir Immune Defic Syndr, 82 (5), pp. 503-513, 2019, ISSN: 1525-4135.
Exposure to toxic metals and polychlorinated biphenyls of adolescents and adults from two atolls in the Tuamotu Archipelago (French Polynesia).Journal Article
Sci Total Environ, 695 , pp. 133791, 2019, ISSN: 0048-9697.
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium.Journal Article
Mol Psychiatry, 24 (12), pp. 1920-1932, 2019, ISSN: 1359-4184.
A Latent Class Analysis of the Social Determinants of Health Impacting Heavy Alcohol Consumption Among Women Living with HIV in Canada: The Canadian HIV Women's Sexual and Reproductive Health Cohort Study.Journal Article
AIDS Behav, 23 (12), pp. 3226-3236, 2019, ISSN: 1090-7165.