Dr. Lucie Jeannotte is a regular researcher at the CHU Research Centre of Québec- Université Laval, Oncology Axis, and Professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of the Faculty of Medicine at Université Laval. She is also a regular researcher at the Centre for Cancer Research at Université Laval. Her research aims at understanding the molecular mechanisms involved in the formation of the mammalian embryo with a specific interest for Hox genes. Hox genes encode transcriptional factors that play key roles in the developmental hierarchy leading to pattern formation of the embryo. Loss of Hox gene function in mice results in numerous malformations of skeleton and organs, among others, that can impair survival. The developmental origin of several diseases, including cancers, reveals how important it is to understand the mechanisms that control embryogenesis.
Function of the Hoxa5 gene in the formation of the respiratory system
Lung development implies a coordinated regulation of numerous molecules and factors. The team of Dr. Jeannotte has characterized the Hoxa5 mutant mouse line et revealed the critical and unique role of this gene in survival at birth. The loss of Hoxa5 function cause severe defects of the respiratory system that result in death of the mutants at birth. The malformations mimic pediatric congenital diseases, such as tracheal stenosis, lung hypoplasia and congenital diaphragmatic hernia as well as chronic obstructive pulmonary diseases (COPD), a major cause of death in the human population. Hoxa5 mutant mice thus provide a unique animal model to further study these pathologies. Dr. Jeannotte is interested in identifying the targets of HOXA5 transcriptional factor in the respiratory system in order to define the molecular mechanisms perturbed by the Hoxa5 mutation that underlie the phenotypes observed and may lead to future therapies.
Role of YY1 in the pathogenesis of the pleuropulmonary blastoma
The pleuropulmonary blastoma (PPB) is a rare pediatric lung tumor that arises during fetal life. It results from the progression of abnormal lung cysts to an aggressive sarcoma with poor survival. The team of Dr. Jeannotte has produced mutant mice devoid of Yy1 function in lung epithelium. This mutation causes lung cysts as those seen in PPB patients. YY1 is a transcription factor essential for embryo development and survival. YY1 expression is reduced in PPB lung tumors raising the hypothesis that the loss of Yy1 function is important for PPB pathogenesis. To determine the role and mechanisms of action of YY1 in PPB, Dr. Jeannotte aims at identifying the mechanisms of action of YY1 in lung formation in order to resolve its implication in PPB formation. These studies may reveal novel molecular targets for the design of effective and innovative therapies and better tools for the diagnosis and prognosis of this severe cancer.
The role of semantic memory in the recognition of emotional valence conveyed by written words.Journal Article
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 27 (2), pp. 270-288, 2020, ISSN: 1382-5585.
Association measures for clustered competing risks.Journal Article
Stat Med, 39 (4), pp. 409-423, 2020, ISSN: 0277-6715.
Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice.Journal Article
Behav Brain Res, 379 , pp. 112348, 2020, ISSN: 0166-4328.
Pharmacists practising in family medicine groups: What are their activities and needs?Journal Article
J Clin Pharm Ther, 45 (1), pp. 105-114, 2020, ISSN: 0269-4727.
Omega-3 fatty acids: new insights into the impact of eicosapentaenoic and docosahexaenoic acids on lipid and lipoprotein metabolism.Journal Article
Curr Opin Lipidol, 31 (1), pp. 38-39, 2020, ISSN: 0957-9672.
Directing hMSCs fate through geometrical cues and mimetics peptides.Journal Article
J Biomed Mater Res A, 108 (2), pp. 201-211, 2020, ISSN: 1549-3296.
Long Working Hours and the Prevalence of Masked and Sustained Hypertension.Journal Article
Hypertension, 75 (2), pp. 532-538, 2020, ISSN: 0194-911X.
Steroid enzyme and receptor expression and regulations in breast tumor samples - A statistical evaluation of public data.Journal Article
J Steroid Biochem Mol Biol, 196 , pp. 105494, 2020, ISSN: 0960-0760.
An Action Research to Optimize the Well-Being of Older People in Nursing Homes: Challenges and Strategies for Implementing a Complex Intervention.Journal Article
J Appl Gerontol, 39 (2), pp. 119-128, 2020, ISSN: 0733-4648.
Acceptability of pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) in Benin: a qualitative study.Journal Article
AIDS Care, 32 (2), pp. 242-248, 2020, ISSN: 0954-0121.