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Neuroscience

Director
Steve Lacroix
Deputy director
Lisa Topolnik
Address
2705, boulevard Laurier, RC-9800
Québec (Québec)
CANADA G1V 4G2
Phone
+1 418-654-2152
Fax
+1 418-654-2753
Email
neurosciences@crchuq.ulaval.ca

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All active clinical studies

The neuroscience group is organized into multidisciplinary teams that study the biological mechanisms underpinning the normal and pathological functioning of the central and peripheral nervous system and the muscular system. Researchers in this field seek to advance our understanding of physiopathology and develop new treatments for deficiencies and disabilities caused by lesions or neurological, psychiatric, and neuromuscular diseases. Research themes concern neurodegenerative, neuromuscular, and neurogenetic diseases, cerebral and spinal lesions and trauma, the regeneration and reorganization of the nervous system, mental health, ophthalmology, the development of biotherapy and standardized clinical evaluation methods, and neuromodulation treatments. Researchers are very active in Université Laval’s Regroupement Neurosciences et Santé mentale (Neurosciences and Mental Health Group).

Recent publications (see all publications in this area)

Duchene B, Iyombe-Engembe JP, Rousseau J, Tremblay JP, Ouellet DL. From gRNA Identification to the Restoration of Dystrophin Expression: A Dystrophin Gene Correction Strategy for Duchenne Muscular Dystrophy Mutations Using the CRISPR-Induced Deletion Method. Methods in molecular biology (Clifton, N.J.) ,  2018. 1687: 267-283
Bernier PJ, Gourdeau C, Carmichael PH, Beauchemin JP, Verreault R, Bouchard RW, Kroger E, Laforce R Jr. Validation and diagnostic accuracy of predictive curves for age-associated longitudinal cognitive decline in older adults. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,  2017. 189: E1472-E1480
Hawkins RFW, Patenaude A, Dumas A, Jain R, Tesfagiorgis Y, Kerfoot S, Matsui T, Gunzer M, Poubelle PE, Larochelle C, Pelletier M, Vallieres L. ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis. JCI insight,  2017. Epub
Wei C, Stock L, Valanejad L, Zalewski ZA, Karns R, Puymirat J, Nelson D, Witte D, Woodgett J, Timchenko NA, Timchenko L. Correction of GSK3beta at young age prevents muscle pathology in mice with myotonic dystrophy type 1. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology,  2017. Epub
Cash DM, Bocchetta M, Thomas DL, Dick KM, van Swieten JC, Borroni B, Galimberti D, Masellis M, Tartaglia MC, Rowe JB, Graff C, Tagliavini F, Frisoni GB, Laforce R Jr, Finger E, de Mendonca A, Sorbi S, Rossor MN, Ourselin S, Rohrer JD, Genetic FTD Initiative, GENFI. Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study. Neurobiology of aging,  2017. Epub
Mercier E, Tardif PA, Cameron PA, Emond M, Moore L, Mitra B, Ouellet MC, Frenette J, de Guise E, Le Sage N. Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review. Brain injury : [BI],  2017. Epub
Carignan D, Herblot S, Laliberte-Gagne ME, Bolduc M, Duval M, Savard P, Leclerc D. Activation of innate immunity in primary human cells using a plant virus derived nanoparticle TLR7/8 agonist. Nanomedicine : the official journal of the American Academy of Nanomedicine,  2017. Epub
St-Amour I, Turgeon A, Goupil C, Planel E, Hebert SS. Co-occurrence of mixed proteinopathies in late-stage Huntington's disease. Acta neuropathologica,  2017. Epub
Sciacca G, Cicchetti F. Mutant huntingtin protein expression and blood-spinal cord barrier dysfunction in Huntington's disease. Annals of neurology,  2017. Epub
Whittington RA, Planel E, Terrando N. Impaired Resolution of Inflammation in Alzheimer's Disease: A Review. Frontiers in immunology,  2017. 8: 1464
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