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Research Center

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Infirmière de recherche

Louis Lacombe

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Neuroscience

Director
Steve Lacroix
Deputy director
Lisa Topolnik
Address
2705, boulevard Laurier, RC-9800
Québec (Québec)
CANADA G1V 4G2
Phone
+1 418-654-2152
Fax
+1 418-654-2753
Email
neurosciences@crchuq.ulaval.ca

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All active clinical studies

The neuroscience group is organized into multidisciplinary teams that study the biological mechanisms underpinning the normal and pathological functioning of the central and peripheral nervous system and the muscular system. Researchers in this field seek to advance our understanding of physiopathology and develop new treatments for deficiencies and disabilities caused by lesions or neurological, psychiatric, and neuromuscular diseases. Research themes concern neurodegenerative, neuromuscular, and neurogenetic diseases, cerebral and spinal lesions and trauma, the regeneration and reorganization of the nervous system, mental health, ophthalmology, the development of biotherapy and standardized clinical evaluation methods, and neuromodulation treatments. Researchers are very active in Université Laval’s Regroupement Neurosciences et Santé mentale (Neurosciences and Mental Health Group).

Recent publications (see all publications in this area)

Lavoie P, Audet ME, Gariepy JL, Savard M, Verreault S, Gourdeau A, Milot G, Carrondo Cottin S. Severe cerebellar hemorrhage following transverse sinus stenting for idiopathic intracranial hypertension. Interventional neuroradiology : journal of peritherapeutic neuroradiology,,  2017. Epub
Iyombe-Engembe JP, Tremblay JP. The advances and challenges of Gene Therapy for Duchenne Muscular Dystrophy Journal of Genetic Medicine and Gene Therapy,  2017. 1: 19-36
Kerdiles O, Layé S, Calon F. Omega-3 polyunsaturated fatty acids and brain health: Preclinical evidence for the prevention of neurodegenerative diseases Trends in food science & technology,  2017.  
Gratuze M, Julien J, Morin F, Marette A, Planel E. Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet. Progress in neuro-psychopharmacology & biological psychiatry,  2017. 79: 452-461
Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK. An environment-dependent transcriptional network specifies human microglia identity. Science,  2017. 356:
Gosselin D, Gougis M, Baque M, Navarro FP, Belgacem MN, Chaussy D, Bourdat AG, Mailley P, Berthier J. Screen-Printed Polyaniline-Based Electrodes for the Real-Time Monitoring of Loop-Mediated Isothermal Amplification Reactions. Analytical chemistry,  2017. 89: 10124-10128
Litim N, Morissette M, Caruso D, Melcangi RC, Di Paolo T. Effect of the 5alpha-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice. The Journal of steroid biochemistry and molecular biology,  2017. Epub
LeBel M, Egarnes B, Brunet A, Lacerte P, Pare A, Lacroix S, Brown JP, Gosselin J. Ly6Chigh monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice. European journal of immunology,  2017. Epub
Wang X, Liu D, Huang HZ, Wang ZH, Hou TY, Yang X, Pang P, Wei N, Zhou YF, Dupras MJ, Calon F, Wang YT, Man HY, Chen JG, Wang JZ, Hebert SS, Lu Y, Zhu LQ. A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease. Biological psychiatry,  2017. Epub
Mercier E, Tardif PA, Cameron P, Batomen Kuimi BL, Emond M, Moore L, Mitra B, Frenette J, de Guise E, Ouellet MC, Bordeleau M, Le Sage N. Prognostic value of S-100ss protein for prediction of post-concussion symptoms following a mild traumatic brain injury: systematic review and meta-analysis. Journal of neurotrauma,  2017. Epub
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