Cortical disinhibitory circuits: cell types, connectivity and function
Centre de recherche du CHU de Québec-Université Laval
The concept of a dynamic excitation/inhibition ratio due to circuit disinhibition, which can shape information flow in cortical circuits during complex behavioral tasks, has arisen as an important and conserved information processing motif. Indeed, in cortical circuits, different subtypes of GABAergic inhibitory interneurons are connected to each other. Moreover, a subpopulation of GABAergic cells that express vasoactive intestinal polypeptide (VIP) selectively innervates inhibitory interneurons. In both cases, circuit disinhibition is a possible outcome of interneuron-to-interneuron signaling. My talk will focus on inhibitory neuron subtypes that are involved in hippocampal disinhibition, with focus on local circuit and long-range synaptic connections that drive disinhibitory function.